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DC Field | Value | Language |
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dc.contributor.author | urpi, mireia | - |
dc.contributor.author | Casas, Rosa | - |
dc.contributor.author | Chiva-Blanch, Gemma | - |
dc.contributor.author | Romero-Mamani, Edwin Saúl | - |
dc.contributor.author | Valderas-Martínez, Palmira | - |
dc.contributor.author | Arranz, Sara | - |
dc.contributor.author | Andres-Lacueva, Cristina | - |
dc.contributor.author | llorach, rafael | - |
dc.contributor.author | Medina-Remón, Alexander | - |
dc.contributor.author | Lamuela-Raventos, Rosa M | - |
dc.contributor.author | Estruch Riba, Ramón | - |
dc.date.accessioned | 2024-01-31T14:03:31Z | - |
dc.date.available | 2024-01-31T14:03:31Z | - |
dc.date.issued | 2012-06-02 | - |
dc.identifier.citation | Urpi-Sarda, M. [Mireia], Casas, R. [Rosa], Chiva-Blanch, G. [Gemma], Romero-Mamani, E. S. [Edwin Saúl], Valderas-Martínez, P. [Palmira], Arranz, S. [Sara], ... & Estruch, R. [Ramon] (2012). Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomarkers related to atherosclerosis. Pharmacological research, 65(6), 577-583. | - |
dc.identifier.issn | 1043-6618MIAR | - |
dc.identifier.uri | http://hdl.handle.net/10609/149531 | - |
dc.description.abstract | Previous epidemiological and feeding studies have observed that adherence to Mediterranean diet (Med-Diet) is associated with reduced cardiovascular risk. However, the molecular mechanisms involved are not fully understood. Since atherosclerosis is nowadays considered a low-grade inflammatory disease, recent studies have explored the anti-inflammatory effects of a Med-Diet intervention on serum and cellular biomarkers related to atherosclerosis. In two sub-studies of the PREDIMED (PREvencion con DIeta MEDiterranea) trial, we analyzed the effects at 3 months of two Med-Diet interventions supplemented with either virgin olive oil (VOO) or nuts compared with a control low-fat diet (LFD). Both Med-Diets showed an anti-inflammatory effect reducing serum C-reactive protein, interleukin-6 (IL6) and endothelial and monocytary adhesion molecules and chemokines (P < 0.05; all), whereas these parameters increased after the LFD intervention (P < 0.05; all). In another substudy, we evaluated the long-term (1 year) effects of these interventions on vascular risk factors in 516 high-risk subjects, as well as the effect of different Med-Diet components in the reduction of these biomarkers. At 1 year, the Med-Diet groups had significant decreases in the plasma concentrations of IL6, tumor necrosis factor receptor (TNFR) 60 and TNFR80 (P < 0.05), while intercellular adhesion molecule 1 (ICAM-1), TNFR60 and TNFR80 concentrations increased in the LFD group (P < 0.002). In addition, those allocated in the highest tertile of VOO and vegetables consumption had a significant diminution of plasma TNFR60 concentration compared with those in tertile 1 (P < 0.02). In conclusion, Med-Diet exerts an anti-inflammatory effect on cardiovascular system since it down-regulates cellular and circulating inflammatory biomarkers related to atherogenesis in subjects at high cardiovascular risk. | en |
dc.format.mimetype | application/pdf | ca |
dc.language.iso | eng | ca |
dc.publisher | Elsevier | ca |
dc.relation.ispartof | Pharmacological Research, 2012, 65(6) | ca |
dc.relation.uri | https://doi.org/10.1016/j.phrs.2012.03.006 | - |
dc.rights | CC BY-NC-ND | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.title | Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomarkers related to atherosclerosis | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.doi | https://doi.org/10.1016/j.phrs.2012.03.006 | - |
dc.type.version | info:eu-repo/semantics/acceptedVersion | - |
Appears in Collections: | Articles Articles cientÍfics |
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Urpi_PharmacologicalResearch_Virgin.pdf | 814,57 kB | Adobe PDF | View/Open |
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