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http://hdl.handle.net/10609/149833
Title: | Estudio integrado de la metilación y expresión génica en sangre y búsqueda de marcas potencialmente asociadas a la enfermedad de Parkinson |
Author: | Paz López, Guillermo |
Tutor: | Brunel, Helena |
Others: | Merino, David |
Abstract: | Parkinson's disease is the second most common neurodegenerative disease, after Alzheimer's, and it is characterized by a degeneration of dopaminergic neurons. For people with Parkinsonism, their suffering is mainly associated with motor problems that hinder their daily lives. In terms of diagnosis, early identification of Parkinson's is essential in the fight against the disease. To achieve early diagnosis, a multitude of biomarkers have been used, ranging from symptomatic markers to neuroimaging. Other paths of study that have also been considered involve analyzing gene expression and DNA methylation. In this study, an integrated analysis of expression and methylation data in blood was chosen to identify possible markers associated with the disease. For this purpose, expression and differential methylation analyses were performed, in addition to their integration. The different analyses allowed the identification of a set of differentially expressed and/or methylated genes, biological processes, and cellular components that had previously been linked to the pathology. Furthermore, it was observed that the variables studied have some ability to differentiate between control samples and Parkinson's samples, although a clear distinction between the two groups was not reached. These results shed light on the potential of blood tissue as a predictor of Parkinsonism. |
Keywords: | metilación enfermedad de Parkinson integración ómica RNA-seq |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | Jun-2023 |
Publication license: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Appears in Collections: | Trabajos finales de carrera, trabajos de investigación, etc. |
Files in This Item:
File | Description | Size | Format | |
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gpazlTFM0623memoria.pdf | Memoria del TFM | 3,58 MB | Adobe PDF | View/Open |
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