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http://hdl.handle.net/10609/105006
Title: Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy
Author: Prados Carrasco, Ferran
Moccia, Marcello
Johnson, Aubrey
Yiannakas, Marios
Grussu, Francesco
Cardoso, Manuel Jorge
Ciccarelli, Olga
Ourselin, Sebastien
Barkhof, Frederik
Gandini Wheeler-Kingshott, Claudia
Others: University College London
Università degli Studi di Pavia
King's College London
Universitat Oberta de Catalunya (UOC)
Keywords: Spinal cord atrophy
GBSI Method
Issue Date: 1-Apr-2020
Publisher: NeuroImage
Citation: Prados, F., Moccia, M., Johnson A., Yiannakas M., Grussu, F., Cardoso, M. J., Ciccarelli, O., Ourselin, S., Barkhof, F., Wheeler-Kingshott, C. (2020). Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy. NeuroImage, 209. doi: 10.1016/j.neuroimage.2019.116489
Also see: https://www.sciencedirect.com/science/article/pii/S1053811919310808
Abstract: Spinal cord atrophy measurements obtained from structural magnetic resonance imaging (MRI) are associated with disability in many neurological diseases and serveasin vivobiomarkers of neurodegeneration. Longitudinal spinal cord atrophy rate is commonly determined from the numerical difference between two volumes (basedon 3D surfacefitting) or two cross-sectional areas (CSA, based on 2D edge detection) obtained at different time-points. Being an indirect measure, atrophy rates aresusceptible to variable segmentation errors at the edge of the spinal cord. To overcome those limitations, we developed a new registration-based pipeline thatmeasures atrophy rates directly. We based our approach on the generalised boundary shift integral (GBSI) method, which registers 2 scans and uses a probabilistic XORmask over the edge of the spinal cord, thereby measuring atrophy more accurately than segmentation-based techniques. Using a large cohort of longitudinal spinalcord images (610 subjects with multiple sclerosis from a multi-centre trial and 52 healthy controls), we demonstrated that GBSI is a sensitive, quantitative andobjective measure of longitudinal spinal cord volume change. The GBSI pipeline is repeatable, reproducible, and provides more precise measurements of longitudinalspinal cord atrophy than segmentation-based methods in longitudinal spinal cord atrophy studies.
Language: English
URI: http://hdl.handle.net/10609/105006
ISSN: 1053-8119MIAR
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