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Title: Búsqueda de nuevas dianas terapéuticas para la esclerosis lateral amiotrófica (ELA)
Author: Peral Martínez, Paula
Director: Cánovas Izquierdo, Javier Luis  
Tutor: Sánchez Martínez, Melchor
Romero Cuevas, Miguel
Keywords: amyotrophic lateral sclerosis
therapeutic targets
Issue Date: Jan-2020
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: Amyotrophic lateral sclerosis, ALS, is a neurodegenerative disease which involves loss of muscle control. As a result , limb mobility and, as the disease progresses, the ability to eat, breathe and communicate are affected. This disease has a low prevalence due to its high mortality and has a higher incidence between the ages of 40 and 70. This disease has been chosen as the subject because of general ignorance and its high morbidity. An integrated team of doctors and various therapies are used to treat this disease, although they only serve to delay symptomatology and prevent complications. Work will focus on drug therapies as they help alleviate many of the symptoms and increase and increase the life expectancy of patients. The objective of this work is to find new therapeutic targets using computational tools. This could open up new lines of research and perhaps can be found a therapy which involves an improvement in the treatment of ALS.
Language: Spanish
Appears in Collections:Bachelor thesis, research projects, etc.

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