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http://hdl.handle.net/10609/110406
Title: Estudio de las bases moleculares del cáncer de mama
Author: Quintairos Rial, Gabriel
Director: Casas Roma, Jordi
Tutor: Barceló, Carles
Keywords: DNA damage response
GSEA
cancer
Issue Date: 8-Jan-2020
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: There are several reasons why DNA damage can occur, which can cause diseases such as cancer. When these damages occur, some mechanisms in our cells initiate a process of DNA damage repair (hereinafter "DDR"). Knowing and understanding these mechanisms can improve cancer risk prediction and treatment in the early stages. The mantle cell lymphoma (hereinafter "MCL") is a disease with poor prognosis and difficult to diagnose. This tumor is characterized by overexpression of cyclin D1 and the binding of these proteins to certain regions of the DNA involved in the regulation of DDR. Breast cancer is the most diagnosed in women above any other type of tumor. Early diagnosis is essential in treatment, since it can determine its survival rate can be greatly reduced. Therefore, is crucial to find relevant biomarkers in order to improve early diagnosis. DDR is a process that is considered to be very important in the development of this tumor. This project aims to analyze the similarity of DDR-regulated gene expression by comparing breast cancer with leukemia. We used the published data sets to generate a genetic signature in which the specifically "enriched" genes are identified in order to study their possible role as a possible therapeutic target and as a biomarker. We used the "R" software to align the readings, generate quality controls and finally generate the genetic signature using Gene Set Enrichment Analysis (GSEA). After the development, several processes common to both types of cancer and DDR have been identified. In addition, we managed to identify those common processes positively enriched by using the Random Forest technique.
Language: Spanish
URI: http://hdl.handle.net/10609/110406
Appears in Collections:Bachelor thesis, research projects, etc.

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