Please use this identifier to cite or link to this item:
http://hdl.handle.net/10609/120686
Title: | Integración de datos ómicos y clínicos: nuevos avances en la frontera entre biología y medicina |
Author: | Hernández de la Fuente, Candelaria Lucía |
Tutor: | Gonzalo Sanz, Ricardo |
Others: | Prados Carrasco, Ferran |
Abstract: | Nowadays, using high-resolution biological data in a Biomedical context is essential. This molecular information, showed in different omics approaches (genomics, transcriptomics, proteomics, metabolomics), explains different sides of the human biological variability. Omics data integration is a procedure usually performed by different methods. However, the inclusion of high-resolution molecular information with non-omics data is more troubled. The aim of the present study is to perform a systematic analysis of the methodologies focused to omics and clinical/epidemiological/demographic information from patients, by the use of alternative biostatistics tests (multivariate, regression or similarity network methods) that are evaluated in terms of their performance. We chose a The Cancer Genome Atlas-TCGA project, composed by around 180 samples analyzed for several omics layers and with a rich clinical information available. Specifically, we focused on gene expression (transcriptomics) and methylation (epigenomics). Our results showed a high heterogeneity among the different methods used, regarding integration process, feature selection (genes/clinical variables) and data mining. The nature and behaviour of the selected outcome could affect the results drawn from the present work. Further studies, based on different datasets or alternative outcome variables, could reach the development of stronger predictive models. |
Keywords: | multi-omic data biomedicine variable selection |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | 24-Jun-2020 |
Publication license: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Appears in Collections: | Trabajos finales de carrera, trabajos de investigación, etc. |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
clhernanTFM0620memoria.pdf | Memoria del TFM | 2,71 MB | Adobe PDF | View/Open |
Share:
This item is licensed under a Creative Commons License