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http://hdl.handle.net/10609/31361
Title: Contamination of genomic databases by HIV-1 and its possible consequences. A study in Bioinformatics.
Author: Romero Fernández-Bravo, Miguel
Keywords: HIV-1
BLASTN
Genomic
Contamination
Issue Date: 17-Mar-2014
Abstract: The bioinformatics Basic Local Alignment Search Tools (BLASTN and TBLASTN) were used to search public databases for nucleic acid (NA) and amino acid (AA) sequences identical or similar to HIV-1 DNA and proteins. Several significant alignments were detected in a variety of non-HIV-1 taxa and other sources deposited in public genomic and protein repositories. Homologies between a number of HIV-1 proteins and those of Candida, Cryptococcus and Schistosoma mansoni are of uncertain significance and suggest the need for further analyses. The overwhelmingly likely cause for these data is contamination.
Description: Peer-reviewed
Language: English
URI: http://hdl.handle.net/10609/31361
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