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|Title:||The hygiene hypothesis revisited : Autoimmune diseases, intestinal microbiota and vitamin D's role|
|Director:||Mach Casellas, Núria|
|Others:||Universitat Oberta de Catalunya|
|Publisher:||Universitat Oberta de Catalunya|
|Abstract:||The hygiene hypothesis postulates that higher levels of hygiene and improper exposure to microorganisms early in childhood could disturb the intestinal microbiome functions resulting in abnormal immune responses that can later lead to allergies and autoimmune diseases. Additionally, vitamin D deficiency and vitamin D receptor (VDR) polymorphisms and function might also trigger abnormal immune responses that can lead to an autoimmune disease. Therefore, this review explores the role Western lifestyle factors that lead to intestinal dysbiosis and vitamin D deficiency, and the effect intestinal microbiota, vitamin D and VDR plays in the pathogenesis of autoimmune diseases in the context of the hygiene hypothesis.|
|Appears in Collections:||Bachelor thesis, research projects, etc.|
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