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Title: The hygiene hypothesis revisited : Autoimmune diseases, intestinal microbiota and vitamin D's role
Author: Clark, Allison
Director: Mach Casellas, Núria
Others: Universitat Oberta de Catalunya
Keywords: vitamin D
gut microbiota
hygiene hypothesis
autoimmune diseases
Western lifestyle
Issue Date: 19-Jul-2016
Publisher: Universitat Oberta de Catalunya
Abstract: The hygiene hypothesis postulates that higher levels of hygiene and improper exposure to microorganisms early in childhood could disturb the intestinal microbiome functions resulting in abnormal immune responses that can later lead to allergies and autoimmune diseases. Additionally, vitamin D deficiency and vitamin D receptor (VDR) polymorphisms and function might also trigger abnormal immune responses that can lead to an autoimmune disease. Therefore, this review explores the role Western lifestyle factors that lead to intestinal dysbiosis and vitamin D deficiency, and the effect intestinal microbiota, vitamin D and VDR plays in the pathogenesis of autoimmune diseases in the context of the hygiene hypothesis.
Language: English
Appears in Collections:Bachelor thesis, research projects, etc.

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