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Title: Bioinformática y Biología: Investigación sobre el desarrollo de nuevos ARNm como posibles marcadores de la LLC y su relación con el estrés oxidativo
Author: Romero Fernández-Bravo, Miguel Ángel
Director: Laia Rosich Moya
Keywords: CLL, Oxidative Stress, HIV-1
Issue Date: 24-May-2017
Publisher: Universitat Oberta de Catalunya
Abstract: The application of bioinformatics tools to study cancer aids the understanding of their genetic origins. This study involved chronic lymphocytic leukaemia (CLL), a haematological malignancy of B-lymphocytes. BIRC3 and POT1 are two genes mutated in patients with CLL. This paper focuses on the search for homologues to these genes as possible markers of CLL. A search of genes associated with CLL returned HIV-1 sequences in cancer associated genes: BIRC3, POT1, PT53 and OXSR1. Oxidative stress may be an underlying factor since it is associated with a range of malignancies, including OXSR1 gene in patients with CLL.
Language: Spanish
Appears in Collections:Bachelor thesis, research projects, etc.

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