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Title: Mutaciones recurrentes en la leucemia linfática crónica: análisis genómico y evolutivo y evaluación de fármacos existentes
Author: Freire Álvarez, María Ruth
Director: Rosich Moya, Laia
Tutor: Pérez Navarro, Antoni  
Merino Arranz, David
Others: Universitat Oberta de Catalunya
Keywords: pharmacology
protein structure
genomic location
Issue Date: Jun-2017
Publisher: Universitat Oberta de Catalunya
Abstract: Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in adults from Western countries. Different massive sequencing studies have shown the existence of recurrent mutations associated with CLL in several genes. In this work different web tools have been employed for the genomic and proteomic analysis of genes for NOTCH1, SF3B1 and MYD88 proteins. In these genes recurrent mutations associated with CLL have been found. With the use of different servers and web tools, information about genomic location of these genes and their mutations has been reported. The same for homology with other genes in different species and tertiary structure of the proteins coded by these genes. Web tools let us know about different drugs associated with these proteins, with a potential use in CLL therapy. All these analysis allow for the genomic and proteomic interpretation of the recurrent mutations.
Language: Spanish
Appears in Collections:Bachelor thesis, research projects, etc.

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