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http://hdl.handle.net/10609/74165
Title: Identificación de neoantígenos a partir de datos de ultrasecuenciación y aplicación posterior en análisis de supervivencia en pacientes con cáncer colorrectal
Author: Gómez Rey, Marina
Director: Morán Moreno, José Antonio
Tutor: Sanz Pamplona, Rebeca
Others: Universitat Oberta de Catalunya
Keywords: neoantigens
immunology
NGS
Issue Date: Jan-2018
Publisher: Universitat Oberta de Catalunya
Abstract: In this project, a prediction and subsequent survival analysis of neoantigens in colorectal cancer is developed. In order to achieve the purposes, the NGS data have been obtained from the TCGA portal and its subsequent analysis has been carried out using bioinformatics tools and specialized web servers. The result obtained was a list of differentiated antigens according to their binding affinity to the MHC-I complex and a survival analysis with neoantigens as a variable predictor. It is concluded that the project has been carried out successfully obtaining a more strict and reliable method of predicting neoantigens.
Language: Spanish
URI: http://hdl.handle.net/10609/74165
Appears in Collections:Bachelor thesis, research projects, etc.

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