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Title: | Visualización mediante shiny de la calidad de los datos de RNA-Seq relacionados con el sistema inmune y el cáncer |
Author: | Ferrer Torres, Adrián |
Tutor: | Gonzalo Sanz, Ricardo |
Others: | Universitat Oberta de Catalunya Morán Moreno, Jose Antonio Ventura, Carles |
Abstract: | Due to the increasing incidence of cancer in the population, it has become the second cause of death worldwide. Due to this, the study of the relation of the immune system with cancer disease is critical to research in what fails and how the expression on lymphocytic cells is modified. Therefore information about immune evasion would be reached leading to possible checkpoints or pharmacological target in which we could treat with different types of drugs, immunotherapy, or other therapies as personalized therapy. In order to conduct a study of genetic expression it is a must to first pre-filter, control and normalize the results obtained samples obtained from a RNA-Seq experiment. This is what is intended in this study, showing also the different stages of results obtained with graphics and tables in an application made with the shiny package. The samples were obtained from the gene expression omnibus webpage. The edgeR and DT packages were used for the application construction. It is as well included in the memory a report of the budget for a small lab and research center that sequences the client¿s genomes as well as other omic studies from other centers as hospitals, institutes and research centers. |
Keywords: | Shiny RNAseq gene expression quality control |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | Feb-2018 |
Publication license: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Appears in Collections: | Trabajos finales de carrera, trabajos de investigación, etc. |
Files in This Item:
File | Description | Size | Format | |
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GSM2461003_LAU125.genes.results.txt | 4,81 MB | Text | View/Open | |
GSM2461005_LAU355.genes.results.txt | 4,81 MB | Text | View/Open | |
GSM2461007_LAU1255.genes.results.txt | 4,81 MB | Text | View/Open | |
GSM2461009_LAU1314.genes.results.txt | 4,81 MB | Text | View/Open | |
Visualización de la calidad de los datos de RNA-Seq relacionados con el sistema inmune y el cáncer visualizados mediante shiny.ppsx | 4,69 MB | Unknown | View/Open | |
adrianferrertTFM0118memoria.pdf | Memoria del TFM | 1,1 MB | Adobe PDF | View/Open |
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