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Title: Implicación de las mutaciones del gen K-RAS en el cáncer de pulmón
Author: Pavón Vizcaíno, Pedro
Director: Olivares Castiñeira, Ivette
Tutor: Ventura Royo, Carles  
Others: Universitat Oberta de Catalunya
Keywords: lung cancer
Issue Date: Jun-2018
Publisher: Universitat Oberta de Catalunya
Abstract: Lung cancer is one of the five cancers that cause the most deaths in the population in Europe today, about 20.1%. Gene mutations in the RAS gene (K-RAS, N-RAS and H-RAS) affect cellular signaling systems, giving the tumor cells some characteristics that cause their behavior to become malignant. The MAPK / ERK pathway is one of the signaling pathways, together with the mutated K-RAS isoform, that is involved in the oncogenesis and development of Non-Small Cell Lung Cancer (NSCLC). Given the complexity of the functioning of the network of cellular signaling pathways and their feedback lines, it is necessary to identify proteins / genes that have an influence on this type of cancer (NSCLC) and on the functioning of the therapies applied to patients who are carriers of the mutated KRAS gene. Therefore, this work has focused on the study of the MAPK / ERK pathway, on KRAS mutations and on the expression of eight genes involved in these pathways, carrying out a study on 30 patients with this type of cancer and mutated KRAS, analyzing the influence of each gene on the prognosis of patients through a comprehensive analysis of survival. The study demonstrates that the variations of the expressions in some of the genes present significant evidence at 5% that influence the survival time of patients with this type of cancer and the effectiveness of the therapies used.
Language: Spanish
Appears in Collections:Bachelor thesis, research projects, etc.

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