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http://hdl.handle.net/10609/82086
Title: Estudio metagenómico de microbioma oral humano con diferente severidad en diabetes tipo 2, caracterización a nivel de composición y funcional
Author: Rodríguez Pérez, Noelia
Director: Morán Moreno, José Antonio
Tutor: Redrejo Rodríguez, Modesto
Others: Universitat Oberta de Catalunya
Keywords: diabetes
periodontitis
Issue Date: 5-Jun-2018
Publisher: Universitat Oberta de Catalunya
Abstract: The purpose of this study has been to characterize type 2 diabetes with different severity from a metagenomic point of view, performing a microbiology and functional analysis. The analysis was applied on data from an observational case-control study performed in Chinese population, with 31 subjects classified into four different groups according to whether they presented type 2 diabetes and periodontitis or not. The gene coding for 16S rRNA was sequenced with the 454 GS FLX Titanium platform. Analysis of alpha and beta diversity as well as taxonomy, were carried out with QIIME2 tool, while the package limma on Rstudio, allowed the calculation of differentially expressed functions in groups of interest, inferred from the 16S rRNA data thanks to PICRUST.
Language: Spanish
URI: http://hdl.handle.net/10609/82086
Appears in Collections:Bachelor thesis, research projects, etc.

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