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Title: Análisis comparativo de biología tumoral y de supervivencia en pacientes con adenocarcinoma pulmonar, con y sin historial de tabaquismo
Author: Guinart Fernández, Esther
Director: Morán Moreno, José Antonio
Tutor: Bassaganyas Bars, Laia
Keywords: NSCLC
tumour biology
smoking history
Issue Date: 5-Jun-2018
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: The goal of this paper is the study of the tumor biology of the lung adenocarcinoma (a subtype of non-small cell lung cancer) in patients with and without smoking history. A lot of research has been made with regards to this type of tumor, above all because it is one of the main causes of death worldwide. There is evidence supporting that one of the most common sources of this cancer is the smoking history. However, this pathology is growing in patients without smoking history, primarily in developed countries, since 30% of new cases occur in such scenarios. This is the reason why this paper intends to find out if there are differences among both groups (one with and the other without smoking history). We will try to find out if the tumor biology in lung adenocarcinoma is different in both control groups: overexpressed vs dowregulated genes. We will perform a survival analysis across groups. Both topics above will be processed and analyzed by a pipeline analysis with R/Bioconductor. The results obtained after this investigation may trigger a need to change the current medical treatment for adenocarcinoma patients with non-smoking history or whether new targets and biomarkers are required given the differences across groups.
Language: Spanish
Appears in Collections:Bachelor thesis, research projects, etc.

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