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Title: Estudio de mutaciones missense neutrales mediante el uso y análisis de datos ómicos
Author: García López, Albert
Director: Morán Moreno, José Antonio
Tutor: Bassaganyas Bars, Laia
Keywords: gene expression
missense mutations
Issue Date: 5-Jun-2018
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: In this thesis, by analysing omics data from several sources, wild-type protein sequences from three out of the four genes selected were detected in three random colorrectal cancer samples coming from a dataset of proteomics data. However, none of the sequences containing a neutral missense mutation were identified. Moreover, as it was proved by statistical tests, selected genes with higher amount of GC content were more expressed than those with a lower GC quantity. Additionally, it was also proved by statistical tests that there were no significant differences between the expression levels of selected genes in cancer cells and in normal cells. Overall, this project aims to pave the way to design a method that allows the detection, quantification and study of neutral missense mutations and understand their influence in multiple pathological processes.
Language: Spanish
Appears in Collections:Bachelor thesis, research projects, etc.

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