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Title: Diseño computacional de fármacos para Niemann Pick tipo C
Author: Sudrià Lopez, Daniel
Director: Marco Galindo, Maria Jesús
Tutor: Sánchez Martínez, Melchor
Keywords: Niemann Pick
Issue Date: 5-Jun-2018
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: Niemann Pick type C (NP-C) is a hereditary neurodegenerative disease with an early onset and severe symptomatology that causes death in few years, usually during childhood. It is caused by mutations on the genes of NPC1 and NPC2, which are lisosomal cholesterol transporters. The aims of this study were to computationally evaluate the effect of such mutations on cholesterol binding, and computationally design potential drugs for the treatment of NP-C. NPC1 mutants were generated via homology modelling and their capability to bind cholesterol was assessed with docking experiments.
Language: Spanish
Appears in Collections:Bachelor thesis, research projects, etc.

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