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Title: The role of transcutaneous Vagus Nerve Stimulaion (t-VNS) paired with tones in the treatment of Tinnitus through the manipulation of neural plasticity. Practicum I
Author: Calduch Ortega, Irene
Tutor: Valero Cabré, Antoni
Keywords: tVNS
neural plasticity
Issue Date: 23-Dec-2018
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: The tinnitus is a sound perception defined as the psychosensory phenomenon experienced in the auditory cortex and different mechanisms can produce it. The tinnitus can be subjective or objective, which means they can be felt as own in the absence of an exterior stimulation and nonobserved by other than the patient or they could be produced by external sources. As it is known, there are different physiopathological theories to explain this phenomenon but we believe that none of them can explain with accuracy the complexity of tinnitus. Hence the project is focus on the demonstration of the changes that the combination of the transcutaneal stimulation of the Vague Nerve (t-VNS) paired with tones can produce in the plasticity of the auditory cortex. Additionally, we will test the effectiveness of the t-VNS paired with tones compared with a single therapy of t-VNS or tones to treat chronic tinnitus as it is shown in animal, particularly rodent, literature that provides perfect and inspiring test bench. We will do the test in three randomized groups of 15 people and hence a total sample of 45 individuals. These individuals have to have a subjective chronic tinnitus derived from exposed-noise hearing loss. One group will receive a therapy of the tVNS combined with tone while the other two groups will receive a single treatment therapy with just tVNS or just tones. The idea is to do a pre-treatment and posttreatment resting state functional magnetic resonance imaging (fMRI) to detect the changes in functional connectivity at rest. Also, to do a comparison between the fMRI of the different groups along with a pre-treatment and post-treatment application of a Tinnitus Questionnaire (TQ) and a Tinnitus Handicap Questionnaire (THQ) to study the improvement of the subjective complaints of the tinnitus.
Language: English
Appears in Collections:Bachelor thesis, research projects, etc.

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