Please use this identifier to cite or link to this item:

http://hdl.handle.net/10609/90846
Title: Estudio poblacional de la mutación KRAS en pacientes con diagnóstico de cáncer de páncreas.
Author: Arcones Martín, Carolina
Director: Olivares Castiñeira, Ivette
Tutor: Ventura Royo, Carles  
Keywords: pancreas cancer
mutation
K-ras
Issue Date: 2-Jan-2019
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: Pancreas cancer has a high mortality rate among the world population. In 90 % of the cases appears as a consequence of the mutation in the KRAS protein. In this work, a descriptive analysis a population study of the sequences of patients with pancreas carcinomas and other types of carcinomas have been carried out in order to evaluate the mutations that appear in the 2nd exon chromosome´s 12 codon 12 the KRAS gene. A study has been done with of DNA where 26 of these sequences belong to pancreatic carcinoma and 69 belong to other types of carcimomas. All the sequences are discharged from the bank of genomics information. The results show that the averages of the mutations in pancreas carninomas are higher than in other kinds of carcinomas obtaining statistically significant differences The results show that the averages of the mutations in pancreas carninomas are higher than in other kinds of carcinomas obtaining statistically significant differences in patients with pancreatic carcinoma through a percentage of the mutations depending on the length of the sequence. In the phylogenetic study, the mutations are grouped by diseases, appreciating the union between the pancreatic samples without mutations and the dispersion in the tree of the other pancreatic sequences, where there is more diversity in genetic changes. Repetitive mutations are shown mainly in pancreatic samples. These results demonstrate their potential influence to develop pancreatic cancer worthy of further studies. The study of these genetic changes could help in early diagnosis, new more effective therapies and improve the prognosis of patients.
Language: Spanish
URI: http://hdl.handle.net/10609/90846
Appears in Collections:Bachelor thesis, research projects, etc.

Share:
Export:
Files in This Item:
File Description SizeFormat 
carconesTFM0119memoria.pdfMemoria del TFM1.05 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons