Please use this identifier to cite or link to this item:

http://hdl.handle.net/10609/92408
Title: A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence
Author: Carr, Rachel
Di Bari, Lorenzo
Lo Piano, Samuele
Parker, David
Peacock, Robert D.
Sanderson, John M.
Keywords: luminescence
europium
Issue Date: 13-Feb-2012
Publisher: Dalton Transactions
Citation: Carr, R., Di Bari, L., Lo Piano, S., Parker, D., Peacock, R. D. & Sanderson, J. M. (2012). A chiral probe for the acute phase proteins alpha-1-acid glycoprotein and alpha-1-antitrypsin based on europium luminescence. Dalton Transactions, 41(), 3154-13158. doi:10.1039/c2dt30143a
Also see: http://dx.doi.org/10.1039/c2dt30143a
Abstract: Reversible and selective binding of a dynamically racemic europium(III) complex to alpha-1-acid glycoprotein and alpha-1-antitrypsin is characterised by a significant change in the europium total emission spectral fingerprint and the switching on of a large circularly polarised luminescence (CPL) signal from the metal centre. Observation of an induced CD into the ligand chromophore in the presence of alpha-1-AGP allows a structure for the protein-bound complex to be postulated. A direct determination of elevated alpha-1-AGP levels in human serum was achieved by monitoring changes in the intensity ratio of Eu emission bands.
Language: English
URI: http://hdl.handle.net/10609/92408
ISSN: 1477-9226MIAR
Appears in Collections:Articles

Share:
Export:
Files in This Item:
There are no files associated with this item.

Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.