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http://hdl.handle.net/10609/92574
Title: Mendelian genes for Parkinson's disease contribute to the sporadic forms of the disease
Author: Spataro, Nino
Calafell Majo, Francesc d'Assis
Cervera Carles, Laura
Casals López, Ferran
Pagonabarraga, Javier
Pascual Sedano, Berta María  
Campolongo Perillo, Antonia
Kulisevsky Bojarski, Jaume  
Lleó Alonso, Alberto
Navarro, Arcadi
Clarimon Echavarria, Jordi
Bosch Fusté, Elena
Others: Universitat Pompeu Fabra
Universitat Autònoma de Barcelona
Universitat Oberta de Catalunya (UOC)
Keywords: parkinson disease
mutation
genome-wide a ssociation study
genes
Issue Date: 11-Dec-2014
Publisher: Human Molecular Genetics
Citation: Spataro, N., Calafell, F., Cervera-Carles, L., Casals, F., Pagonabarraga, J., Pascual-Sedano, B., Campolongo, A., Kulisevsky, J., Lleó, A., Navarro, A., Clarimón, J. & Bosch, E. (2015). Mendelian genes for parkinson's disease contribute to the sporadic forms of the disease. Human Molecular Genetics, 24(7), 2023-2034. doi: 10.1093/hmg/ddu616
Also see: https://academic.oup.com/hmg/article/24/7/2023/597304
Abstract: Parkinson's disease (PD) can be divided into familial (Mendelian) and sporadic forms. A number of causal genes have been discovered for the Mendelian form, which constitutes 10-20% of the total cases. Genome-wide association studies have successfully uncovered a number of susceptibility loci for sporadic cases but those only explain a small fraction (6-7%) of PD heritability. It has been observed that some genes that confer susceptibility to PD through common risk variants also contain rare causing mutations for the Mendelian forms of the disease. These results suggest a possible functional link between Mendelian and sporadic PD and led us to investigate the role that rare and low-frequency variants could have on the sporadic form. Through a targeting approach, we have resequenced at 49× coverage the exons and regulatory regions of 38 genes (including Mendelian and susceptibility PD genes) in 249 sporadic PD patients and 145 unrelated controls of European origin. Unlike susceptibility genes, Mendelian genes showa clear general enrichment of rare functional variants in PD cases, observed directly as well as with Tajima's D statistic and several collapsing methods. Our findings suggest that rare variation on PD Mendelian genes may have a role in the sporadic forms of the disease.
Language: English
URI: http://hdl.handle.net/10609/92574
ISSN: 1460-2083MIAR

0964-6906MIAR
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