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dc.contributor.authorPastor, Pau-
dc.contributor.authorMoreno Izco, Fermín-
dc.contributor.authorClarimon Echavarria, Jordi-
dc.contributor.authorRuiz, Agustín-
dc.contributor.authorCombarros, Onofre-
dc.contributor.authorCalero Lara, Miguel-
dc.contributor.authorLópez de Munain, Adolfo-
dc.contributor.authorBullido, María Jesús-
dc.contributor.authorMartinez De Pancorbo, Marian-
dc.contributor.authorCarro Díaz, Eva-
dc.contributor.authorAntonell, Anna-
dc.contributor.authorCoto, Eliecer-
dc.contributor.authorOrtega Cubero, Sara-
dc.contributor.authorHernandez, Isabel-
dc.contributor.authorTárraga, Lluís-
dc.contributor.authorBoada Rovira, Mercè-
dc.contributor.authorLleó Alonso, Alberto-
dc.contributor.authorDols Icardo, Oriol-
dc.contributor.authorKulisevsky Bojarski, Jaume-
dc.contributor.authorInfante, Jon-
dc.contributor.authorRábano, Alberto-
dc.contributor.authorFernández Blázquez, Miguel Ángel-
dc.contributor.authorValentí, Meritxell-
dc.contributor.authorIndakoetxea, Begoña-
dc.contributor.authorBarandiaran, Myriam-
dc.contributor.authorGorostidi, Ana-
dc.contributor.authorFrank García, Ana-
dc.contributor.authorSastre, Isabel-
dc.contributor.authorLorenzo, Elena-
dc.contributor.authorPastor, María A.-
dc.contributor.authorElcoroaristizabal Martín, Xabier-
dc.contributor.authorLennarz, Martina-
dc.contributor.authorMaier, Wolfgang-
dc.contributor.authorRámirez, Alfredo-
dc.contributor.authorSerrano Ríos, Manuel-
dc.contributor.authorLee, Susee E.-
dc.contributor.authorSánchez Juan, Pascual-
dc.contributor.authorVázquez Higuera, José Luis-
dc.contributor.otherInstituto de Salud Carlos III-
dc.contributor.otherUniversidad Pública de Navarra-
dc.contributor.otherUniversidad del País Vasco-
dc.contributor.otherUniversidad Autónoma de Madrid-
dc.contributor.otherFundació ACE. Institut Català de Neurociències Aplicades-
dc.contributor.otherUniversity of Bonn-
dc.contributor.otherUniversity of California-
dc.contributor.otherUniversitat de Barcelona-
dc.contributor.otherUniversitat Autònoma de Barcelona-
dc.contributor.otherUniversitat Oberta de Catalunya (UOC)-
dc.date.accessioned2019-04-02T13:44:43Z-
dc.date.available2019-04-02T13:44:43Z-
dc.date.issued2015-09-29-
dc.identifier.citationPastor, P., Moreno, F., Clarimón, J., Ruiz, Agustín, Combarros, O., Calero, M., López De Munain, A., Bullido, M.J., De Pancorbo, M., Carro, E., Antonell, A., Coto, E., Ortega Cubero, S., Hernandez, I., Tárraga, L., Boada, M., Lleó, A., Dols Icardo, O., Kulisevsky, J., Vázquez Higuera, J.L., Infante, Jon, Rábano, A., Fernández Blázquez, M.A., Valentí, M., Indakoetxea, B., Barandiaran, M., Gorostidi, A., Frank García, A., Sastre, I., Lorenzo, E., Pastor, M., Elcoroaristizabal, X., Lennarz, M., Maier, W., Ramírez, A., Serrano Ríos, M., Lee, S.E. & Sánchez Juan, P. (2015). MAPT H1 haplotype is associated with late-onset Alzheimer's disease risk in APOE epsilon 4 noncarriers: results from the dementia genetics Spanish consortium. Journal of Alzheimer's Disease, 49(2), 343-352. doi: 10.3233/JAD-150555-
dc.identifier.issn1387-2877MIAR
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dc.identifier.issn1875-8908MIAR
-
dc.identifier.urihttp://hdl.handle.net/10609/92826-
dc.description.abstractThe MAPT H1 haplotype has been linked to several disorders, but its relationship with Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p.A152T) has been linked with frontotemporal dementia (FTD) and AD. We genotyped H1/H2 and p.A152T MAPT in 11,572 subjects from Spain (4,327 AD, 563 FTD, 648 Parkinson's disease (PD), 84 progressive supranuclear palsy (PSP), and 5,950 healthy controls). Additionally, we included 101 individuals from 21 families with genetic FTD. MAPT p.A152T was borderline significantly associated with FTD [odds ratio (OR)=2.03; p=0.063], but not with AD. MAPT H1 haplotype was associated with AD risk (OR=1.12; p=0.0005). Stratification analysis showed that this association was mainly driven by APOE epsilon4 noncarriers (OR=1.14; p=0.0025). MAPT H1 was also associated with risk for PD (OR=1.30; p=0.0003) and PSP (OR=3.18; p=8.59 × 10-8) but not FTD. Our results suggest that the MAPT H1 haplotype increases the risk of PD, PSP, and non-APOE epsilon4 AD.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherJournal of Alzheimer's Disease-
dc.relation.ispartofJournal of Alzheimer's Disease, 2015, 49(2)-
dc.relation.urihttps://digital.csic.es/bitstream/10261/139904/1/SastreI_MAPT1HaplotypeIsAssocieatedWithLate-Onset.pdf-
dc.rights(c) Author/s & (c) Journal-
dc.subjectA152Ten
dc.subjectAlzheimer's diseaseen
dc.subjectfrontotemporal dementiaen
dc.subjectgenetic associationen
dc.subjectH1H2en
dc.subjectMAPTen
dc.subjectA152Tes
dc.subjectenfermedad de Alzheimeres
dc.subjectdemencia frontotemporales
dc.subjectasociación genéticaes
dc.subjectH1H2es
dc.subjectMAPTes
dc.subjectA152Tca
dc.subjectmalaltia d'Alzheimerca
dc.subjectdemència frontotemporalca
dc.subjectassociació genèticaca
dc.subjectH1H2ca
dc.subject.lcshAlzheimer's diseaseen
dc.titleMAPT H1 haplotype is associated with late-onset Alzheimer's disease risk in APOE epsilon 4 noncarriers: results from the dementia genetics Spanish consortium-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.subject.lemacAlzheimer, Malaltia d'ca
dc.subject.lcshesAlzheimer, Enfermedad dees
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.doi10.3233/JAD-150555-
dc.relation.projectIDinfo:eu-repo/grantAgreement/SAF2010-22329-C02-01-
dc.relation.projectIDinfo:eu-repo/grantAgreement/SAF2010-15558-
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI13/02434-
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI12/03005-
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI12/01311-
dc.relation.projectIDinfo:eu-repo/grantAgreement/ PI12/00045-
dc.relation.projectIDinfo:eu-repo/grantAgreement/PI12/02288-
dc.relation.projectIDinfo:eu-repo/grantAgreement/JPND-PI11/03028-
dc.relation.projectIDinfo:eu-repo/grantAgreement/CSD2010-00045-
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