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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pastor, Pau | - |
dc.contributor.author | Moreno Izco, Fermín | - |
dc.contributor.author | Clarimón, Jordi | - |
dc.contributor.author | Ruiz, Agustín | - |
dc.contributor.author | Combarros, Onofre | - |
dc.contributor.author | Calero Lara, Miguel | - |
dc.contributor.author | López de Munain, Adolfo | - |
dc.contributor.author | Bullido, María Jesús | - |
dc.contributor.author | Martinez De Pancorbo, Marian | - |
dc.contributor.author | Carro Díaz, Eva | - |
dc.contributor.author | Antonell, Anna | - |
dc.contributor.author | Coto, Eliecer | - |
dc.contributor.author | Ortega Cubero, Sara | - |
dc.contributor.author | Hernandez, Isabel | - |
dc.contributor.author | Tárraga, Lluís | - |
dc.contributor.author | Boada Rovira, Mercè | - |
dc.contributor.author | Lleó, Alberto | - |
dc.contributor.author | Dols Icardo, Oriol | - |
dc.contributor.author | Kulisevsky, Jaime | - |
dc.contributor.author | Infante, Jon | - |
dc.contributor.author | Rábano, Alberto | - |
dc.contributor.author | Fernández Blázquez, Miguel Ángel | - |
dc.contributor.author | Valentí, Meritxell | - |
dc.contributor.author | Indakoetxea, Begoña | - |
dc.contributor.author | Barandiaran, Myriam | - |
dc.contributor.author | Gorostidi, Ana | - |
dc.contributor.author | Frank García, Ana | - |
dc.contributor.author | Sastre, Isabel | - |
dc.contributor.author | Lorenzo, Elena | - |
dc.contributor.author | Pastor, María A. | - |
dc.contributor.author | Elcoroaristizabal Martín, Xabier | - |
dc.contributor.author | Lennarz, Martina | - |
dc.contributor.author | Maier, Wolfgang | - |
dc.contributor.author | Rámirez, Alfredo | - |
dc.contributor.author | Serrano Ríos, Manuel | - |
dc.contributor.author | Lee, Susee E. | - |
dc.contributor.author | Sánchez Juan, Pascual | - |
dc.contributor.author | Vázquez Higuera, José Luis | - |
dc.contributor.other | Instituto de Salud Carlos III | - |
dc.contributor.other | Universidad Pública de Navarra | - |
dc.contributor.other | Universidad del País Vasco | - |
dc.contributor.other | Universidad Autónoma de Madrid | - |
dc.contributor.other | Fundació ACE. Institut Català de Neurociències Aplicades | - |
dc.contributor.other | University of Bonn | - |
dc.contributor.other | University of California | - |
dc.contributor.other | Universitat de Barcelona (UB) | - |
dc.contributor.other | Universitat Autònoma de Barcelona (UAB) | - |
dc.contributor.other | Universitat Oberta de Catalunya (UOC) | - |
dc.date.accessioned | 2019-04-02T13:44:43Z | - |
dc.date.available | 2019-04-02T13:44:43Z | - |
dc.date.issued | 2015-09-29 | - |
dc.identifier.citation | Pastor, P., Moreno, F., Clarimón, J., Ruiz, Agustín, Combarros, O., Calero, M., López De Munain, A., Bullido, M.J., De Pancorbo, M., Carro, E., Antonell, A., Coto, E., Ortega Cubero, S., Hernandez, I., Tárraga, L., Boada, M., Lleó, A., Dols Icardo, O., Kulisevsky, J., Vázquez Higuera, J.L., Infante, Jon, Rábano, A., Fernández Blázquez, M.A., Valentí, M., Indakoetxea, B., Barandiaran, M., Gorostidi, A., Frank García, A., Sastre, I., Lorenzo, E., Pastor, M., Elcoroaristizabal, X., Lennarz, M., Maier, W., Ramírez, A., Serrano Ríos, M., Lee, S.E. & Sánchez Juan, P. (2015). MAPT H1 haplotype is associated with late-onset Alzheimer's disease risk in APOE epsilon 4 noncarriers: results from the dementia genetics Spanish consortium. Journal of Alzheimer's Disease, 49(2), 343-352. doi: 10.3233/JAD-150555 | - |
dc.identifier.issn | 1387-2877MIAR | - |
dc.identifier.issn | 1875-8908MIAR | - |
dc.identifier.uri | http://hdl.handle.net/10609/92826 | - |
dc.description.abstract | The MAPT H1 haplotype has been linked to several disorders, but its relationship with Alzheimer's disease (AD) remains controversial. A rare variant in MAPT (p.A152T) has been linked with frontotemporal dementia (FTD) and AD. We genotyped H1/H2 and p.A152T MAPT in 11,572 subjects from Spain (4,327 AD, 563 FTD, 648 Parkinson's disease (PD), 84 progressive supranuclear palsy (PSP), and 5,950 healthy controls). Additionally, we included 101 individuals from 21 families with genetic FTD. MAPT p.A152T was borderline significantly associated with FTD [odds ratio (OR)=2.03; p=0.063], but not with AD. MAPT H1 haplotype was associated with AD risk (OR=1.12; p=0.0005). Stratification analysis showed that this association was mainly driven by APOE epsilon4 noncarriers (OR=1.14; p=0.0025). MAPT H1 was also associated with risk for PD (OR=1.30; p=0.0003) and PSP (OR=3.18; p=8.59 × 10-8) but not FTD. Our results suggest that the MAPT H1 haplotype increases the risk of PD, PSP, and non-APOE epsilon4 AD. | en |
dc.language.iso | eng | - |
dc.publisher | Journal of Alzheimer's Disease | - |
dc.relation.ispartof | Journal of Alzheimer's Disease, 2015, 49(2) | - |
dc.relation.uri | https://www.doi.org/10.3233/JAD-150555 | - |
dc.subject | A152T | en |
dc.subject | Alzheimer's disease | en |
dc.subject | frontotemporal dementia | en |
dc.subject | genetic association | en |
dc.subject | H1H2 | en |
dc.subject | MAPT | en |
dc.subject | A152T | es |
dc.subject | enfermedad de Alzheimer | es |
dc.subject | demencia frontotemporal | es |
dc.subject | asociación genética | es |
dc.subject | H1H2 | es |
dc.subject | MAPT | es |
dc.subject | A152T | ca |
dc.subject | malaltia d'Alzheimer | ca |
dc.subject | demència frontotemporal | ca |
dc.subject | associació genètica | ca |
dc.subject | H1H2 | ca |
dc.subject.lcsh | Alzheimer's disease | en |
dc.title | MAPT H1 haplotype is associated with late-onset Alzheimer's disease risk in APOE epsilon 4 noncarriers: results from the dementia genetics Spanish consortium | - |
dc.type | info:eu-repo/semantics/article | - |
dc.subject.lemac | Alzheimer, Malaltia d' | ca |
dc.subject.lcshes | Alzheimer, Enfermedad de | es |
dc.rights.accessRights | info:eu-repo/semantics/closedAccess | - |
dc.identifier.doi | 10.3233/JAD-150555 | - |
dc.gir.id | AR/0000004575 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/SAF2010-22329-C02-01 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/SAF2010-15558 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/PI13/02434 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/PI12/03005 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/PI12/01311 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/ PI12/00045 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/PI12/02288 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/JPND-PI11/03028 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/CSD2010-00045 | - |
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