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Title: Regional overlap of pathologies in lewy body disorders
Author: Colom-Cadena, Martí
Grau Rivera, Oriol
Planellas, Lluís
Cerquera Cleves, Catalina
Morenas, Estrella
Helgueta Romero, Sergio
Muñoz Llahuna, Laia
Kulisevsky Bojarski, Jaume  
Marti, Maria Jose
Tolosa, Eduard S.
Clarimon Echavarria, Jordi
Lleó Alonso, Alberto
Gelpi, Ellen
Others: Universitat Autònoma de Barcelona
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Universitat de Barcelona
Universitat Oberta de Catalunya (UOC)
Keywords: dementia with Lewy bodies
Parkinson disease dementia
Parkinson disease
Issue Date: 3-Mar-2017
Publisher: Journal of Neuropathology and Experimental Neurology
Citation: Colom-Cadena, M., Grau-Rivera, O., Planellas, L., Cerquera, C., Morenas, E., Helgueta, S., Muñoz, L., Kulisevsky, J., Marti, M. Jose, Tolosa, E., Clarimon, J., Lleó, A. & Gelpi, E. (2017). Regional Overlap of Pathologies in Lewy Body Disorders. Journal of Neuropathology and Experimental Neurology, 76(3), 216-224. doi: 10.1093/jnen/nlx002
Project identifier: info:eu-repo/grantAgreement/20141610
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Abstract: Lewy body disorders (LBD) are common neurodegenerative diseases characterized by the presence of aggregated a-synuclein in Lewy bodies and Lewy neurites in the central and peripheral nervous systems. The brains of patients with LBD often display other comorbid pathologies, i.e. insoluble tau, b-amyloid aggregates, TAR DNA-binding protein 43 (TDP-43) deposits, and argyrophilic grain disease (AGD). The incidence and physiological relevance of these concurrent pathological findings remain controversial. We performed a semiquantitative detailed mapping of a-synuclein, tau, bamyloid (Ab), TDP-43, and AGD pathologies in 17 areas in 63 LBD cases (44 with Parkinson disease [PD], 28 with dementia, and 19 with dementia with Lewy bodies). APOE and MAPT genetic variants were also investigated. A majority of LBD cases had 2 or 3 concomitant findings, particularly Alzheimer disease-related pathology. Pathological stages of tau, b-amyloid and a-synuclein pathologies were increased in cases with dementia. Ab score was the best correlate of the time to dementia in PD. In addition, b-amyloid deposition correlated with a-synuclein load in all groups. MAPT H1 haplotype did not influence any assessed pathology in PD. These results highlight the common concurrence of pathologies in patients with LBD that may have an impact on the clinical expression of the diseases.
Language: English
ISSN: 0022-3069MIAR

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