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http://hdl.handle.net/10609/93108
Title: Unexpected improvement of hand motor function with a left temporoparietal low-frequency repetitive transcranial magnetic stimulation regime suppressing auditory hallucinations in a brainstem chronic stroke patient
Author: Thomas, Fanny
Bouaziz, Noomane
Amengual Roig, Julià Lluís
Andrianisaina, Palmyre Schenin King
Gaudeau-Bosma, Christian
Moulier, Virginie
Valero Cabré, Antoni
Januel, Dominique
Others: Universitat Oberta de Catalunya (UOC)
Keywords: brainstem stroke patient
auditory hallucinations
repetitive transcranial magnetic stimulation
left temporoparietal junction
motor function
Issue Date: 28-Nov-2017
Publisher: Frontiers in Psychiatry
Citation: Thomas, F., Bouaziz, N., Amengual, J.L., Andrianisaina, P.S.K., Gaudeau-Bosma, C., Moulier, V., Valero-Cabré, A. & Januel, D. (2017). Unexpected improvement of hand motor function with a left temporoparietal low-frequency repetitive transcranial magnetic stimulation regime suppressing auditory hallucinations in a brainstem chronic stroke patient. Frontiers in Psychiatry, 8(). doi: 10.3389/fpsyt.2017.00262
Also see: https://www.frontiersin.org/articles/10.3389/fpsyt.2017.00262/full
Abstract: We here report paradoxical hand function recovery in a 61-year-old male tetra-paretic chronic patient following a stroke of the brainstem (with highly degraded right and abolished left-hand finger flexion/extension disabling him to manipulate objects) who experienced insidious auditory hallucinations (AHs) 4 years after such event. Symptomatic treatment for AHs was provided with periodical double sessions of low-frequency repetitive transcranial magnetic stimulation (rTMS) (daily 1 Hz, 2 × 1,200 pulses interleaved by 1 h interval) delivered to the left temporoparietal junction across two periods of 5 and 3 weeks, respectively. At the end of each stimulation period, AHs disappeared completely. Most surprisingly and totally unexpectedly, the patient experienced beneficial improvements of long-lasting impairments in his right-hand function. Detailed examination of onset and offset of rTMS stimulation regimes strongly suggests a temporal relation with the remission and re-appearance of AHs and also with a fragile but clinically meaningful improvements of right (but not left) hand function contingent to the accrual of stimulation sessions. On the basis of post-recovery magnetic resonance imaging structural and functional evidence, mechanistic hypotheses that could subtend such unexpected motor recovery are critically discussed.
Language: English
URI: http://hdl.handle.net/10609/93108
ISSN: 1664-0640MIAR
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