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dc.contributor.authorRomera Liebana, Laura-
dc.contributor.authorOrfila, Francesc-
dc.contributor.authorSegura, Josep Maria-
dc.contributor.authorReal, Jordi-
dc.contributor.authorFabra, Maria Lluïsa-
dc.contributor.authorMöller, Mercedes-
dc.contributor.authorLancho, Santiago-
dc.contributor.authorRamirez, Anna-
dc.contributor.authorMartí, Núria-
dc.contributor.authorCullell, Montserrat-
dc.contributor.authorBastida, Núria-
dc.contributor.authorMartinez, Dolors-
dc.contributor.authorGiné Garriga, Maria-
dc.contributor.authorCendrós Ramirez, Patricia-
dc.contributor.authorBistuer Lacarra, Ana-
dc.contributor.authorPérez, Elena-
dc.contributor.authorFabregat Casamitjana, Maria Assumpta-
dc.contributor.authorFoz Gil, Gonçal-
dc.contributor.otherInstitut Català de la Salut-
dc.contributor.otherUniversitat Autònoma de Barcelona (UAB)-
dc.contributor.otherUniversitat Ramon Llull-
dc.contributor.otherUniversitat Oberta de Catalunya (UOC)-
dc.date.accessioned2019-04-15T11:37:13Z-
dc.date.available2019-04-15T11:37:13Z-
dc.date.issued2018-01-16-
dc.identifier.citationRomera-Liebana, L., Orfila, F., Segura, J. M., Real, J., Fabra, M. L., Möller, M., . . . Foz, G. (2018). Effects of a primary care-based multifactorial intervention on physical and cognitive function in frail, elderly individuals: A randomized controlled trial. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 73(12), 1668-1674. doi:10.1093/gerona/glx259en
dc.identifier.issn1079-5006MIAR
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dc.identifier.issn1758-535XMIAR
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dc.identifier.urihttp://hdl.handle.net/10609/93194-
dc.description.abstractBackground: Detecting and managing frailty at early stages can prevent disability and other adverse outcomes. The study aim was to evaluate whether a multifactorial intervention program could modify physical and cognitive frailty parameters in elderly individuals. Methods: We conducted a multicenter, randomized, single-blind, parallel-group trial in community-living prefrail/frail elderly individuals in Barcelona. A total of 352 patients, aged ¿65 years old with positive frailty screening, was randomized into two groups to receive a 12-week multidisciplinary intervention or usual care, with concealed allocation. The intervention consisted of: exercise training, intake of hyperproteic nutritional shakes, memory training, and medication review. Main outcome assessments with multivariate analysis were conducted at 3 and 18 months. Results: A total of 347 participants (98.6%) completed the study, mean age 77.3 years, 89 prefrail subjects (25.3%), and 75.3% female (n = 265). Eighteen-month assessments were performed in 76% of the sample. After 3 and 18 months, adjusted means difference between-groups showed significant improvements for the intervention group in all comparisons: Short Physical Performance Battery score improved 1.58 and 1.36 points (p < .001), handgrip strength 2.84 and 2.49 kg (p < .001), functional reach 4.3 and 4.52 cm (p < .001), and number of prescriptions decreased 1.39 and 1.09 (p < .001), respectively. Neurocognitive battery also showed significant improvements across all dimensions at 3 and 18 months. Conclusions: A physical, nutritional, neurocognitive, and pharmacological multifaceted intervention was effective in reversing frailty measures both at short-term and 18 months. Lasting benefits of a multi-intervention program among frail elderly individuals encourage its prioritization.en
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherThe journals of gerontology. Series A, Biological sciences and medical sciences-
dc.relation.urihttps://academic.oup.com/biomedgerontology/article-pdf/73/12/1668/26677503/glx259.pdf-
dc.rightsimplied-oa-
dc.titleEffects of a Primary Care-Based Multifactorial Intervention on Physical and Cognitive Function in Frail, Elderly Individuals: A Randomized Controlled Trial-
dc.typeinfo:eu-repo/semantics/article-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.doi10.1093/gerona/glx259-
dc.gir.idAR/xxx-
dc.type.versioninfo:eu-repo/semantics/publishedVersion-
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