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Title: Estudio personalizado de datos omicos en paragangliomas y feocromocitomas
Author: Vázquez Cuesta, Silvia Noemí
Director: Prados Carrasco, Ferran
Tutor: Bassaganyas Bars, Laia
Keywords: omics
Issue Date: 12-Jun-2019
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: Pheochromocytomas and paragangliomas are neuroendocrine tumors that are considered strongly influenced by genetics, since approximately 40% of patients suffer some mutation in the germ line. In addition to mutations in the germ line, somatic mutations, gene expression and methylation patterns have been found, which have allowed their classification into two large groups. Even so, these studies have been carried out in cohorts and a more personalized approach was needed for each type of patient. The data analyzed in this study were from "The Cancer Genome Atlas" project. There were data from 179 cases between pheochromocytomas and paragangliomas. We analyzed data of copy number alterations, gene expression, mutations and methylation. Web applications such as CNApp have been used for the analysis of CNA data and the rest of the data were analyzed with R and the TCGAbiolinks package. With the integration of the different types of data, results have been obtained in each tumor group, some data appear common in all groups, such as functions of alterations in cell adhesion or cell differentiation, but some groups appear alterations in functions that may be more related with the aggressiveness of one tumor in particular, as angiogenesis processes and cell signaling. In this work we have seen that, although these tumors can be very similar in some ways, in others they differ, and these data are important both for the prognosis and for future treatments.
Language: Spanish
Appears in Collections:Bachelor thesis, research projects, etc.

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