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Title: Exploring the genomic landscape of lung adenocarcinoma using the TCGA database
Author: Abarrategui Martinez, Leire
Tutor: Yolanda Guillén Montalbán
Keywords: Lung adenocarcinoma
genetic mutations
Issue Date: 4-Jun-2019
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: Lung adenocarcinoma is a common type of lung cancer and the leading cause of cancer death worldwide. This project explores the genomic landscape of lung adenocarcinoma from 508 samples belonging to the TCGA-LUAD cohort, using different bioinformatics tools. In the study, driver genes of lung adenocarcinoma, differentially expressed genes and the metabolic pathways and biological processes enriched by them were analysed. In addition, collected drugs in DGIdb for each type of mutation were identified. For this propose, TCGAbiolinks and maftools libraries from bioconductor and intOGen web platform were used. As a result, 38 genes related to lung adenocarcinoma were obtained, the most common were TP53 and KRAS, as previously observed in other studies. Moreover, TP53, KRAS, KEAP1, PLCB1 and PTPRD genes were related with smoking. Furthermore, 2,590 over-expressed and 1,281 under-expressed genes were identified. Differentially represented important cancer pathways were determined, such as cell cycle regulation and MAPK signalling. Finally, only drugs for 10 genes commonly mutated in cancer were identified, therefore this may open new future research lines.
Language: English
Appears in Collections:Bachelor thesis, research projects, etc.

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