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Title: Análisis de la virulencia de proteínas multifuncionales mediante bioinformática
Author: Nájar García, Araceli
Director: Ventura Royo, Carles  
Tutor: Franco Serrano, Luis
Keywords: virulence
multifunctional proteins
Issue Date: Jun-2019
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: Moonlighting or multifunctional proteins are able to execute more than one function. Nearly 25% of the moonlighting proteins described in databases are involved in the virulence of pathogens. However, the existence of common motifs or patterns among these virulence-related proteins has not been determined yet. Therefore, the main goal of this project has been to analyze bioinformatically the moonlighting proteins involved in virulence. Specifically, the methodology of this work consisted in searching common motifs, analyzing binding partners of these proteins and studying regions involved in the interaction with plasminogen. One of the main results has been a list of 240 moonlighting proteins related to virulence, mostly enzymes from the primary metabolism of several microorganisms which main moonlighting function is binding to host proteins. The results also include common motifs in some of these proteins, a program to search them, an analysis of the location of these in each protein sequence and a list of amino acids involved in the interaction of certain moonlighting proteins with plasminogen. To summarize, the results of this work suggest that some enolases and multifunctional GAPDH have common motifs, sometimes close to or involved in the areas of interaction between these proteins and plasminogen. In addition, some of these moonlighting proteins usually interact with the same plasminogen residues.
Language: Spanish
Appears in Collections:Bachelor thesis, research projects, etc.

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