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http://hdl.handle.net/10609/99625
Title: Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis
Author: Brown, James William L.
Chowdhury, Azmain
Kanber, Baris
Prados Carrasco, Ferran
Eshaghi, Arman
Sudre, Carole H.
Pardini, Matteo
Samson, Rebecca S.
van de Pavert, Steven H.P.
Gandini Wheeler-Kingshott, Claudia
Chard, Declan T.
Keywords: Primary progressive multiple sclerosis
Secondary progressive multiple sclerosis
Magnetisation transfer ratio
Normal-appearing white matter
Issue Date: 8-Apr-2019
Publisher: Multiple Sclerosis Journal
Citation: Brown, J., Chowdhury, A., Kanber, B., Prados, F., Eshaghi, A., Sudre, C. H., Pardini, M., Samson, R. S., van de Pavert, S.H.P., Gandini Wheeler-Kinshott, C. & Chard, D. T. (2019). Magnetisation transfer ratio abnormalities in primary and secondary progressive multiple sclerosis. Multiple Sclerosis Journal, (), 1-9. doi: 10.1177/1352458519841810
Also see: https://doi.org/10.1177/1352458519841810
Abstract: Background: In relapse-onset multiple sclerosis (MS), tissue abnormality - as assessed with magnetisation transfer ratio (MTR) imaging - is greater in the outer cortical and inner periventricular layers. The cause of this remains unknown but meningeal inflammation has been implicated, particularly lymphoid follicles, which are seen in secondary progressive (SP) but not primary progressive (PP) MS. Cortical and periventricular MTR gradients might, therefore, differ in PPMS and SPMS if these follicles are responsible. Objective: We assessed cortical and periventricular MTR gradients in PPMS, and compared gradients between people with PPMS and SPMS. Methods: Using an optimised processing pipeline, periventricular normal-appearing white matter and cortical grey-matter MTR gradients were compared between 51 healthy controls and 63 people with progressive MS (28 PPMS, 35 SPMS). Results: The periventricular gradient was significantly shallower in healthy controls (0.122 percentage units (pu)/band) compared to PPMS (0.952 pu/band, p<0.0001) and SPMS (1.360 pu/band, p<0.0001). The cortical gradient was also significantly shallower in healthy controls (-2.860 pu/band) compared to PPMS (-3.214 pu/band, p=0.038) and SPMS (-3.328 pu/band, p=0.016). Conclusion: Abnormal periventricular and cortical MTR gradients occur in both PPMS and SPMS, suggesting comparable underlying pathological processes.
Language: English
URI: http://hdl.handle.net/10609/99625
ISSN: 1352-4585MIAR

1477-0970MIAR
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