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Títol: Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults
Autoria: Argüello González, Guillermo
Bonet-Carne, Elisenda  
Girona, Mònica  
Esteve Sole, Ana
Bobillo Perez, Sara
Burgos-Artizzu, Xavier Paolo  
Mensa Vilaró, Anna
Codina, Anna
Hernández Garcia, María
Jou, Cristina
Alsina, Laia
Jordan, Iolanda  
Altres: Universitat Oberta de Catalunya
Universitat de Barcelona (UB)
Institut de Recerca Sant Joan de Déu
Citació: Girona Alarcon, M et al. (2022). Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults. iScience (25), https://doi.org/10.1016/ j.isci.2021.103595
Resum: It is unclear why COVID-19 ranges from asymptomatic to severe. When SARS-CoV-2 is detected, interferon (IFN) response is activated. When it is insufficient or delayed, it might lead to overproduction of cytokines and severe COVID-19. The aim was to compare cytokine and IFN patterns in children and adults with differing severity with SARS-CoV-2.It was a prospective, observational study, including 84 patients. Patients with moderate/severe disease had higher cytokines' values than patients with mild disease (p< 0.001).Two IFN genes were selected to build a decision tree for severity classification: SOCS1 (representative of the rest of the IFN genes) and CIITA (inverse correlation). Low values of CIITA and high values of SOCS1 indicated severe disease. This method correctly classified 33/38(86.8%) of children and 27/34 (79.4%) of adults. To conclude, patients with severe disease had an elevated cytokine pattern, which correlated with the IFN response, with low CIITA and high SOCS1 values.
Paraules clau: COVID-19
SARS-CoV-2
interferó
citoquines
DOI: http://doi.org/10.1016/j.isci.2021.103595
Tipus de document: info:eu-repo/semantics/article
Versió del document: info:eu-repo/semantics/publishedVersion
Data de publicació: 21-gen-2022
Llicència de publicació: https://creativecommons.org/licenses/by-nc-nd/4.0/  
eu-repo/semantics/openAccess
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