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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Argüello González, Guillermo | - |
dc.contributor.author | Bonet-Carne, Elisenda | - |
dc.contributor.author | Girona, Mònica | - |
dc.contributor.author | Esteve Sole, Ana | - |
dc.contributor.author | Bobillo Perez, Sara | - |
dc.contributor.author | Burgos-Artizzu, Xavier Paolo | - |
dc.contributor.author | Mensa Vilaró, Anna | - |
dc.contributor.author | Codina, Anna | - |
dc.contributor.author | Hernández Garcia, María | - |
dc.contributor.author | Jou, Cristina | - |
dc.contributor.author | Alsina, Laia | - |
dc.contributor.author | Jordan, Iolanda | - |
dc.contributor.other | Universitat Oberta de Catalunya | - |
dc.contributor.other | Universitat de Barcelona (UB) | - |
dc.contributor.other | Institut de Recerca Sant Joan de Déu | - |
dc.date.accessioned | 2022-03-30T08:43:09Z | - |
dc.date.available | 2022-03-30T08:43:09Z | - |
dc.date.issued | 2022-01-21 | - |
dc.identifier.citation | Girona Alarcon, M et al. (2022). Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults. iScience (25), https://doi.org/10.1016/ j.isci.2021.103595 | - |
dc.identifier.issn | 2589-0042MIAR | - |
dc.identifier.uri | http://hdl.handle.net/10609/142426 | - |
dc.description.abstract | It is unclear why COVID-19 ranges from asymptomatic to severe. When SARS-CoV-2 is detected, interferon (IFN) response is activated. When it is insufficient or delayed, it might lead to overproduction of cytokines and severe COVID-19. The aim was to compare cytokine and IFN patterns in children and adults with differing severity with SARS-CoV-2.It was a prospective, observational study, including 84 patients. Patients with moderate/severe disease had higher cytokines' values than patients with mild disease (p< 0.001).Two IFN genes were selected to build a decision tree for severity classification: SOCS1 (representative of the rest of the IFN genes) and CIITA (inverse correlation). Low values of CIITA and high values of SOCS1 indicated severe disease. This method correctly classified 33/38(86.8%) of children and 27/34 (79.4%) of adults. To conclude, patients with severe disease had an elevated cytokine pattern, which correlated with the IFN response, with low CIITA and high SOCS1 values. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | iScience | - |
dc.relation.ispartof | iScience, 2022, 25(1). | - |
dc.relation.ispartofseries | 25;1 | - |
dc.relation.uri | http://doi.org/10.1016/j.isci.2021.103595 | - |
dc.rights | CC BY-NC-ND 4.0 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | - |
dc.rights.uri | eu-repo/semantics/openAccess | - |
dc.subject | COVID-19 | en |
dc.subject | SARS-CoV-2 | en |
dc.subject | COVID-19 | es |
dc.subject | COVID-19 | ca |
dc.subject | SARS-CoV-2 | es |
dc.subject | SARS-CoV-2 | ca |
dc.subject | interferó | ca |
dc.subject | interferón | es |
dc.subject | interferon | en |
dc.subject | citoquines | ca |
dc.subject | citoquinas | es |
dc.subject | cytokines | en |
dc.subject.lcsh | virology | - |
dc.title | Low levels of CIITA and high levels of SOCS1 predict COVID-19 disease severity in children and adults | en |
dc.type | info:eu-repo/semantics/article | - |
dc.subject.lemac | virologia | - |
dc.subject.lcshes | virología | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.doi | http://doi.org/10.1016/j.isci.2021.103595 | - |
dc.gir.id | AR/0000009453 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI18/00223 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/FI19/00208 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI21/00211 | - |
dc.type.version | info:eu-repo/semantics/publishedVersion | - |
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