Please use this identifier to cite or link to this item: http://hdl.handle.net/10609/151691
Title: Cognitive profile and cardiovascular risk Factors in older adults with mild cognitive impairment
Author: Vázquez De Sebastián, Julia  
Ortiz Zúñiga, Ángel Michael  
Ciudin Mihai, Andreea  
Ars , Joan  
Inzitari, Marco  
Simó Canonge, Rafael  
Hernandez, Cristina  
Ariño-Blasco, Sergio  
Barahona, Maria-José  
Franco-Romero, M  
Gironès, Xavier  
CRESPO MARAVER, MARIA CRUZ  
Carles, Joan  
Castellano-Tejedor, Carmina  
The DIALCAT Consortium
Citation: Vazquez de Sebastián, J. [Julia], Ortiz Zuñiga, A. [Angel], Ciudin, A. [Andreea], Ars, J. [Joan], Inzitari, M. [Marco], Simó, R. [Rafael], Hernández, C. [Cristina], Ariño Blasco, S. [Sergio], Barahona, M.J. [Maria José], Franco, M. [Maite], Gironès, X. [Xavier,] Crespo Maraver, M.C. [María Cruz], Rovira, J.C. [Joan Carles] & Castellano-Tejedor, C. [Carmina]. (2024). Cognitive profile and cardiovascular risk Factors in older adults with mild cognitive impairment. International Journal of Environmental Research and Public Health, 21(4), 1-15. doi: 10.3390/ijerph21040500
Abstract: The prevalence of cardiovascular risk factors (CVRFs) in the older adults population and their specific impact on their cognitive profiles still requires further research. For this purpose, a cross-sectional study was carried out to describe the presence of CVRFs and their association with cognitive performance in a sample of older adults (65–85 years old) with Mild Cognitive Impairment (MCI). Participants (n = 185) were divided into three groups concerning their cardiovascular risk level determined by the presence of different CVRFs, including Type 2 Diabetes (T2D), dyslipidemia, hypertension, and obesity. The primary outcome measures were the participant’s scores in the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Sociodemographic, clinical, and psychosocial data were collected. Non-parametrical statistical analyses and effect sizes were calculated. Findings revealed that a greater presence of CVRFs was not associated with a worse overall cognitive performance. High-risk patients were more likely to have significantly worse performance in the attentional domain compared to medium-risk (p = 0.029, r = 0.42) and compared to low-risk (p = 0.041, r = 0.35), specifically in the digits repetition subtest (p = 0.042). T2D alone was the CVRF associated with cognitive differences (p = 0.037, r = 0.32), possibly mediated by the duration of the condition. Consequently, a higher presence of CVRFs did not lead to a worse overall cognitive performance. However, high-risk individuals were more likely to experience cognitive impairment, particularly in the attentional domain. T2D played a significant role in these cognitive profile differences, possibly influenced by its duration.
Keywords: cardiovascular risk factors
type 2 diabetes
cognitive impairment
neuropsychological profile
mild cognitive impairment
older adults
DOI: https://doi.org/10.3390/ijerph21040500
Document type: info:eu-repo/semantics/article
Version: info:eu-repo/semantics/publishedVersion
Issue Date: 18-Apr-2024
Publication license: http://creativecommons.org/licenses/by/3.0/es/  
Linked data: https://mdpi.altmetric.com/details/162650009
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