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Title: | Characterization of white matter hyperintensities in Down syndrome |
Author: | Morcillo-Nieto, Alejandra O. ![]() Zsadanyi, Sara ![]() Arriola Infante, José Enrique ![]() Carmona Iragui, Maria ![]() Montal, Victor ![]() Pegueroles, Jordi ![]() Rozalem Aranha, Mateus Vaqué-Alcázar, Lídia ![]() Padilla, Concepción Benejam, Bessy ![]() Videla Toro, Laura ![]() Barroeta, Isabel ![]() Fernandez, Susana ![]() Altuna, Miren Giménez, Sandra ![]() González-Ortiz, Sofía Bargalló, Núria Ribas, Laia ![]() Arranz, Javier ![]() Torres, Soraya Iulita, M. Florencia ![]() Belbin, Olivia ![]() Camacho, Valle ![]() Alcolea, Daniel ![]() Lleó, Alberto ![]() Fortea, Juan ![]() Bejanin, Alexandre ![]() |
Citation: | Morcillo-Nieto, A. [Alejandra O.], Zsadanyi, S. [Sara E.], Arriola-Infante, J. [Jose E.], Carmona-Iragui, M. [Maria], Montal, V. [Victor], Pegueroles, J. [Jordi], Rozalem Aranha, M. [Mateus], Vaqué-Alcázar, L. [Lídia], Padilla, C. [Concepción], Benejam, B. [Bessy], Videla, L. [Laura], Barroeta, I. [Isabel]. Fernandez, S. [Susana], Altuna, M. [Miren], Giménez, S. [Sandra], González-Ortiz, S. [Sofía ], Bargalló, N. [Núria], Ribas, L. [Laia], Arranz, J. [Javier], Torres, S. [Soraya], Florencia Iulita, M. [Maria], Belbin, O. [Olivia], Camacho, V. [Valle], Alcolea, D. [Daniel], Lleó, A. [Alberto], Fortea, J. [Juan], Bejanin, A. [Alexandre]. (2024). Characterization of white matter hyperintensities in Down syndrome. Alzheimer’s Dement, 20:6527–6541. DOI: 10.1002/alz.14146 |
Abstract: | INTRODUCTION: In Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer’s disease (AD) biomarkers remain largely unexplored. METHODS: In 261 DS adults and 131 euploid controls, fluid-attenuated inver- sion recovery magnetic resonance imaging scans were segmented and WMHs were extracted in concentric white matter layers and lobar regions. We tested associations with AD clinical stages, sociodemographic data, cerebrospinal fluid (CSF) AD biomarkers, and gray matter (GM) volume. RESULTS: In DS, total WMHs arose at age 43 and showed stronger associations with age than in controls. WMH volume increased along the AD continuum, particularly in periventricular regions, and frontal, parietal, and occipital lobes. Associations were found with CSF biomarkers and temporo-parietal GM volumes. DISCUSSION: WMHs increase 10 years before AD symptom onset in DS and are closely linked with AD biomarkers and neurodegeneration. This suggests a direct connection to AD pathophysiology, independent of vascular risks. |
Keywords: | alzheimer’s disease down syndrome magnetic resonance imaging neuroimaging small vessel disease white matter hyperintensities |
DOI: | https:doi.org/10.1002/alz.14146 |
Document type: | info:eu-repo/semantics/article |
Version: | info:eu-repo/semantics/publishedVersion |
Issue Date: | 2-Jul-2024 |
Publication license: | http://creativecommons.org/licenses/by-nc/3.0/es/ ![]() |
Appears in Collections: | Articles Articles cientÍfics |
Files in This Item:
File | Description | Size | Format | |
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Padilla_Concepción_Alzheimers_Dementia_Characterization.pdf | 7,8 MB | Adobe PDF | ![]() View/Open |
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