Please use this identifier to cite or link to this item: http://hdl.handle.net/10609/151739
Title: Characterization of white matter hyperintensities in Down syndrome
Author: Morcillo-Nieto, Alejandra O.  
Zsadanyi, Sara  
Arriola Infante, José Enrique  
Carmona Iragui, Maria  
Montal, Victor  
Pegueroles, Jordi  
Rozalem Aranha, Mateus
Vaqué-Alcázar, Lídia  
Padilla, Concepción
Benejam, Bessy  
Videla Toro, Laura  
Barroeta, Isabel  
Fernandez, Susana  
Altuna, Miren
Giménez, Sandra  
González-Ortiz, Sofía
Bargalló, Núria
Ribas, Laia  
Arranz, Javier  
Torres, Soraya
Iulita, M. Florencia  
Belbin, Olivia  
Camacho, Valle  
Alcolea, Daniel  
Lleó, Alberto  
Fortea, Juan  
Bejanin, Alexandre  
Citation: Morcillo-Nieto, A. [Alejandra O.], Zsadanyi, S. [Sara E.], Arriola-Infante, J. [Jose E.], Carmona-Iragui, M. [Maria], Montal, V. [Victor], Pegueroles, J. [Jordi], Rozalem Aranha, M. [Mateus], Vaqué-Alcázar, L. [Lídia], Padilla, C. [Concepción], Benejam, B. [Bessy], Videla, L. [Laura], Barroeta, I. [Isabel]. Fernandez, S. [Susana], Altuna, M. [Miren], Giménez, S. [Sandra], González-Ortiz, S. [Sofía ], Bargalló, N. [Núria], Ribas, L. [Laia], Arranz, J. [Javier], Torres, S. [Soraya], Florencia Iulita, M. [Maria], Belbin, O. [Olivia], Camacho, V. [Valle], Alcolea, D. [Daniel], Lleó, A. [Alberto], Fortea, J. [Juan], Bejanin, A. [Alexandre]. (2024). Characterization of white matter hyperintensities in Down syndrome. Alzheimer’s Dement, 20:6527–6541. DOI: 10.1002/alz.14146
Abstract: INTRODUCTION: In Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer’s disease (AD) biomarkers remain largely unexplored. METHODS: In 261 DS adults and 131 euploid controls, fluid-attenuated inver- sion recovery magnetic resonance imaging scans were segmented and WMHs were extracted in concentric white matter layers and lobar regions. We tested associations with AD clinical stages, sociodemographic data, cerebrospinal fluid (CSF) AD biomarkers, and gray matter (GM) volume. RESULTS: In DS, total WMHs arose at age 43 and showed stronger associations with age than in controls. WMH volume increased along the AD continuum, particularly in periventricular regions, and frontal, parietal, and occipital lobes. Associations were found with CSF biomarkers and temporo-parietal GM volumes. DISCUSSION: WMHs increase 10 years before AD symptom onset in DS and are closely linked with AD biomarkers and neurodegeneration. This suggests a direct connection to AD pathophysiology, independent of vascular risks.
Keywords: alzheimer’s disease
down syndrome
magnetic resonance imaging
neuroimaging
small vessel disease
white matter hyperintensities
DOI: https:doi.org/10.1002/alz.14146
Document type: info:eu-repo/semantics/article
Version: info:eu-repo/semantics/publishedVersion
Issue Date: 2-Jul-2024
Publication license: http://creativecommons.org/licenses/by-nc/3.0/es/  
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