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Title: | Optic chiasm involvement in multiple sclerosis, aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein–associated disease |
Author: | Bianchi, Alessia ![]() Cortese, Rosa ![]() Prados Carrasco, Ferran ![]() TUR, CARMEN ![]() Kanber, Baris Yiannakas, Marios ![]() Samson, Rebecca ![]() De Angelis, Floriana ![]() Magnollay, Lise ![]() Jacob, Anu Brownlee, Wallace ![]() Trip, Anand nicholas, richard ![]() Hacohen, Yael Barkhof, Frederik ![]() Ciccarelli, Olga ![]() Toosy, Ahmed ![]() |
Citation: | Bianchi, A. [Alessia], Cortese, R. [Rosa], Prados, F. [Ferran], Tur, C. [Carmen], Kanber, B. [Baris], Yiannakas, M.C. [Marios C.], Samson, R. [Rebecca], De Angelis, F. [Floriana], Magnollay, L. [Lise], Jacob, A. [Anu], Brownlee, W. [Wallace], Trip, A. [Anand], Nicholas, R. [Richard], Hacohen, Y. [Yael], Barkhof, F. [Frederik], Ciccarelli, O. [Olga] & Toosy, A.T. [Ahmed T.]. (2024). Optic chiasm involvement in multiple sclerosis, aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein-associated disease. Multiple Sclerosis Journal, 30(6), 674-86. doi: 10.1177/13524585241240420 |
Abstract: | Background: Optic neuritis (ON) is a common feature of inflammatory demyelinating diseases (IDDs) such as multiple sclerosis (MS), aquaporin 4-antibody neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). However, the involvement of the optic chiasm (OC) in IDD has not been fully investigated. Aims: To examine OC differences in non-acute IDD patients with (ON+) and without ON (ON−) using magnetisation transfer ratio (MTR), to compare differences between MS, AQP4 + NMOSD and MOGAD and understand their associations with other neuro-ophthalmological markers. Methods: Twenty-eight relapsing-remitting multiple sclerosis (RRMS), 24 AQP4 + NMOSD, 28 MOGAD patients and 32 healthy controls (HCs) underwent clinical evaluation, MRI and optical coherence tomography (OCT) scan. Multivariable linear regression models were applied. Results: ON + IDD patients showed lower OC MTR than HCs (28.87 ± 4.58 vs 31.65 ± 4.93; p = 0.004). When compared with HCs, lower OC MTR was found in ON + AQP4 + NMOSD (28.55 ± 4.18 vs 31.65 ± 4.93; p = 0.020) and MOGAD (28.73 ± 4.99 vs 31.65 ± 4.93; p = 0.007) and in ON− AQP4 + NMOSD (28.37 ± 7.27 vs 31.65 ± 4.93; p = 0.035). ON+ RRMS had lower MTR than ON− RRMS (28.87 ± 4.58 vs 30.99 ± 4.76; p = 0.038). Lower OC MTR was associated with higher number of ON (regression coefficient (RC) = −1.15, 95% confidence interval (CI) = −1.819 to −0.490, p = 0.001), worse visual acuity (RC = −0.026, 95% CI = −0.041 to −0.011, p = 0.001) and lower peripapillary retinal nerve fibre layer (pRNFL) thickness (RC = 1.129, 95% CI = 0.199 to 2.059, p = 0.018) when considering the whole IDD group. Conclusion: OC microstructural damage indicates prior ON in IDD and is linked to reduced vision and thinner pRNFL. |
Keywords: | optic chiasm optic neuritis multiple sclerosis aquaporin4-antibody neuromyelitis optica spectrum disorder myelin oligodendrocyte glycoprotein antibody–associated disease magnetisation transfer ratio |
DOI: | https://doi.org/10.1177/13524585241240420 |
Document type: | info:eu-repo/semantics/article |
Version: | info:eu-repo/semantics/publishedVersion |
Issue Date: | May-2024 |
Publication license: | http://creativecommons.org/licenses/by/3.0/es/ ![]() |
Appears in Collections: | Articles cientÍfics Articles |
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