Please use this identifier to cite or link to this item: http://hdl.handle.net/10609/151775
Title: Optic chiasm involvement in multiple sclerosis, aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein–associated disease
Author: Bianchi, Alessia  
Cortese, Rosa  
Prados Carrasco, Ferran  
TUR, CARMEN  
Kanber, Baris
Yiannakas, Marios  
Samson, Rebecca  
De Angelis, Floriana  
Magnollay, Lise  
Jacob, Anu
Brownlee, Wallace  
Trip, Anand
nicholas, richard  
Hacohen, Yael
Barkhof, Frederik  
Ciccarelli, Olga  
Toosy, Ahmed  
Citation: Bianchi, A. [Alessia], Cortese, R. [Rosa], Prados, F. [Ferran], Tur, C. [Carmen], Kanber, B. [Baris], Yiannakas, M.C. [Marios C.], Samson, R. [Rebecca], De Angelis, F. [Floriana], Magnollay, L. [Lise], Jacob, A. [Anu], Brownlee, W. [Wallace], Trip, A. [Anand], Nicholas, R. [Richard], Hacohen, Y. [Yael], Barkhof, F. [Frederik], Ciccarelli, O. [Olga] & Toosy, A.T. [Ahmed T.]. (2024). Optic chiasm involvement in multiple sclerosis, aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein-associated disease. Multiple Sclerosis Journal, 30(6), 674-86. doi: 10.1177/13524585241240420
Abstract: Background: Optic neuritis (ON) is a common feature of inflammatory demyelinating diseases (IDDs) such as multiple sclerosis (MS), aquaporin 4-antibody neuromyelitis optica spectrum disorder (AQP4 + NMOSD) and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD). However, the involvement of the optic chiasm (OC) in IDD has not been fully investigated. Aims: To examine OC differences in non-acute IDD patients with (ON+) and without ON (ON−) using magnetisation transfer ratio (MTR), to compare differences between MS, AQP4 + NMOSD and MOGAD and understand their associations with other neuro-ophthalmological markers. Methods: Twenty-eight relapsing-remitting multiple sclerosis (RRMS), 24 AQP4 + NMOSD, 28 MOGAD patients and 32 healthy controls (HCs) underwent clinical evaluation, MRI and optical coherence tomography (OCT) scan. Multivariable linear regression models were applied. Results: ON + IDD patients showed lower OC MTR than HCs (28.87 ± 4.58 vs 31.65 ± 4.93; p = 0.004). When compared with HCs, lower OC MTR was found in ON + AQP4 + NMOSD (28.55 ± 4.18 vs 31.65 ± 4.93; p = 0.020) and MOGAD (28.73 ± 4.99 vs 31.65 ± 4.93; p = 0.007) and in ON− AQP4 + NMOSD (28.37 ± 7.27 vs 31.65 ± 4.93; p = 0.035). ON+ RRMS had lower MTR than ON− RRMS (28.87 ± 4.58 vs 30.99 ± 4.76; p = 0.038). Lower OC MTR was associated with higher number of ON (regression coefficient (RC) = −1.15, 95% confidence interval (CI) = −1.819 to −0.490, p = 0.001), worse visual acuity (RC = −0.026, 95% CI = −0.041 to −0.011, p = 0.001) and lower peripapillary retinal nerve fibre layer (pRNFL) thickness (RC = 1.129, 95% CI = 0.199 to 2.059, p = 0.018) when considering the whole IDD group. Conclusion: OC microstructural damage indicates prior ON in IDD and is linked to reduced vision and thinner pRNFL.
Keywords: optic chiasm
optic neuritis
multiple sclerosis
aquaporin4-antibody neuromyelitis optica spectrum disorder
myelin oligodendrocyte glycoprotein antibody–associated disease
magnetisation transfer ratio
DOI: https://doi.org/10.1177/13524585241240420
Document type: info:eu-repo/semantics/article
Version: info:eu-repo/semantics/publishedVersion
Issue Date: May-2024
Publication license: http://creativecommons.org/licenses/by/3.0/es/  
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