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Title: Búsqueda computacional de fármacos diabetes tipo 2 y esclerosis lateral amiotrófica
Author: Maroto Ferrer, Alberto
Tutor: Sánchez Martínez, Melchor
Others: Universitat Oberta de Catalunya
Marco-Galindo, Maria-Jesús
Keywords: quantitative structure-activity relationship (QSAR)
pharmaceutical industry
Issue Date: 25-Dec-2016
Publisher: Universitat Oberta de Catalunya
Abstract: The aim of this study is to find novel molecules that interact with the known targets of these diseases. After doing a structure-based screening between these proteins and the molecules of the libraries diverse and iPPI, we have found some molecules with desirable safety and physicochemical properties. We have analyzed the results using CAESAR test, which is based of QSAR methodology. Using these compounds as a template we have generated new libraries by similarity methods (ligand-based screening).
Language: Spanish
Appears in Collections:Trabajos finales de carrera, trabajos de investigación, etc.

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