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Title: Papel de la microbiota intestinal en diferentes estrategias de bajada de peso
Author: Moreno Indias, Isabel
Tutor: Ylla Bou, Guillem
Others: Universitat Oberta de Catalunya
Merino, David  
Keywords: obesity
Issue Date: 5-Jun-2018
Publisher: Universitat Oberta de Catalunya
Abstract: Gut microbiota is a key factor in metabolic diseases like obesity. Gut microbiota has a role in weight loss. Different interventions for weight loss could have a different response in the gut microbiota profile. Thus, the aim of the current study is to study different interventions for weight loss in patients with a different degree of obesity: bariatric surgery, Mediterranean diet and ketogenic diet. Stool and blood were sampled before and after the interventions for the bacterial 16 rRNA sequencing by NGS (Ion S5, Thermofisher) of the stool samples and the measurement of biochemical variables in blood. QIIME2 was used for the sequences analysis and translation into bacteria, PICRUSt for their functional inference and MicrobiomeAnalyst and STAMP, respectively, for their statistical analysis. There were interesting differences between the analyzed procedures. Bariatric surgery, which obtained the highest weight loss, although it did not radically change the gut microbiota profile, it changed its functionality. Mediterranean diet, which obtained the least weight losses, registered a significant increase of the diversity and SCFAs producers. The ketogenic diet, which was in a intermediate point about the weight loss, produced a drastic change in the gut microbiota profile and its potential functionality. This study could open new research in obesity therapies targeting gut microbiota.
Language: Spanish
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