Cognitive-enhanced eHealth psychosocial stepped intervention for managing breast cancer-related cognitive impairment: protocol for a randomized controlled trial

Serra-Blasco, Maria; Souto Sampera, Arnau; Medina, Joan C.; Flix-Valle, Aida; Ciria Suarez, Laura; Arizu-Onassis, Alejandra; Ruiz-Romeo, Marina; Jansen, Femke; Rodríguez, Ana; PERNAS SIMON, SONIA; Ochoa, Cristian

doi:https://doi.org/10.1177/20552076241257082

Cognitive-enhanced eHealth psychosocial stepped intervention for managing breast cancer-related cognitive impairment: protocol for a randomized controlled trial

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Abstract

Introduction: Breast cancer often leads to cancer-related cognitive impairment (CRCI), which includes both objective and subjective cognitive deficits. While psychosocial interventions benefit quality of life and distress reduction, their impact on cognitive deficits is uncertain. This study evaluates the integration of a cognitive module into a digital psychosocial intervention for breast cancer patients. Methods: In this randomized controlled trial (RCT), 88 recently diagnosed breast cancer (BC) patients will receive the ICOnnecta't program (control group) – a digital stepped intervention addressing a variety of psychosocial needs. The experimental group (n = 88) will receive ICOnnecta’t plus a cognitive module. Assessments at baseline, 3, 6, and 12 months will measure the interventions’ impact on cognition, emotional distress, medication adherence, quality of life, post-traumatic stress, work functioning and healthcare experience. Feasibility and cost-utility analyses will also be conducted. Results: The cognitive module includes three levels. The first level contains a cognitive screening using FACT-Cog Perceived Cognitive Impairment (PCI). Patients with PCI <54 progress to a cognitive psychoeducational campus (Level 2) with content on cognitive education, behavioural strategies and mindfulness. Patients with persistent or worsened PCI (≥6) after 3 months move to Level 3, an online cognitive training through CogniFit software delivered twice a week over 12 weeks. Conclusions: This study assesses whether integrating a cognitive module into a digital psychosocial intervention improves objective and subjective cognition in breast cancer patients. Secondary outcomes explore cognitive improvement's impact on psychosocial variables. The research will contribute to testing efficacious approaches for detecting and addressing cognitive dysfunction in breast cancer patients.

DOI

https://doi.org/10.1177/20552076241257082

Project Identifier

info:eu-repo/grantAgreement/PI22/01255
info:eu-repo/grantAgreement/PI15/01278
info:eu-repo/grantAgreement/PI19/01880
info:eu-repo/grantAgreement/2020/FI/B00288
info:eu-repo/grantAgreement/2021/SGR01003

Citation

Serra Blasco, M. [Maria], Souto Sampera, A. [Arnau], Medina, J.C. [Joan C.], Flix Valle, A. [Aida], Ciria Suarez, L. [Laura], Arizu-Onassis, A. [Alejandra], Ruiz Romeo, M [Marina], Jansen, F. [Femke], Rodríguez, A. [Ana] & Pernas, S. [Sonia]. (2024). Cognitive-enhanced eHealth psychosocial stepped intervention for managing breast cancer-related cognitive impairment: protocol for a randomized controlled trial. Digital Health, 10, 1-17. doi: 10.1177/20552076241257082

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