2026-04-07T13:11:57Zhttps://openaccess.uoc.edu/server/oai/requestoai:openaccess.uoc.edu:10609/1475592025-07-04T12:43:11Zcom_10609_4421com_10609_67col_10609_39862col_10609_92386
Repositori Institucional (O2)
author
Boughanem, Hatim
author
Canudas, Silvia
author
Hernández-Alonso, Pablo
author
Becerra-Tomás, Nerea
author
BABIO SÁNCHEZ, NANCY
author
Salas-Salvadó, Jordi
author
MACIAS-GONZALEZ, MANUEL
other
Universitat Rovira i Virgili (URV)
other
Institut d’Investigació Sanitària Pere Virgili (IISPV)
other
Instituto de Salud Carlos III
other
Universitat de Barcelona (UB)
other
Universitat Rovira i Virgili (URV)
other
Universitat Oberta de Catalunya (UOC)
other
Universitat de València
other
Imperial College London
2023-02-27T11:13:03Z
2023-02-27T11:13:03Z
2021-06-04
Boughanem, Hatim, B., Canudas, A., Hernandez-Alonso, P., Becerra-Tomás, N., Babio, N., Salas-Salvadó, J., & Macias-Gonzalez, M. (2021) Vitamin D Intake and the Risk of Colorectal Cancer: An Updated Meta-Analysis and Systematic Review of Case-Control and Prospective Cohort Studies. Cancers,13(11), 2814. doi: 10.3390/cancers13112814
2072-6694
https://hdl.handle.net/10609/147559
https://doi.org/10.3390/cancers13112814
Obesity, a sedentary lifestyle, high red meat consumption and alcohol, and tobacco are considered the driving factors behind colorectal cancer (CRC) worldwide. Both diet and lifestyle are recognized to play an important role in the prevention of CRC. Forty years later, the vitamin D–cancer hypothesis is considered consistent. However, the relationship between low vitamin D intake and CRC is still controversial. The aim of this meta-analysis is to determine the associations between Vitamin D intake and CRC. MEDLINE-PubMed and Cochrane databases were searched up to May 2020 for studies evaluating the association between vitamin D intake (from foods and supplements) and CRC. Two reviewers, working independently, screened all titles and abstracts to identify the studies that met the inclusion criteria (case-control or prospective cohort (PC) studies published in English). Data were pooled by the generic inverse variance method using a random or fixed effect model. Heterogeneity was identified using the Cochran Q-test and quantified by the I2 statistic. A total of 31 original studies were included for the quantitative meta-analysis, comprising a total 47.540 cases and 70.567 controls in case-control studies, and a total of 14.676 CRC-incident cases (out of 808.130 subjects in PC studies) from 17 countries. A significant 25% lower risk was reported comparing the highest vs. the lowest dietary vitamin D consumption and CRC risk (odds ratio (95% confidence interval): 0.75 (0.67; 0.85)) in case-control studies, whereas a non-significant association was reported in case of prospective studies (hazard ratio (95% confidence interval): 0.94 (0.79; 1.11). The present meta-analysis demonstrates that high dietary vitamin D is associated to CRC prevention. However, larger and high-quality prospective studies and clinical trials are warranted to confirm this association.
eng
CC BY 4.0
vitamin D intake
meta-analysis
systematic review
colorectal cancer
incidence
case-control
prospective
ingesta de vitamina D
metaanàlisi
revisió sistemàtica
càncer de colon
incidència
control de casos
prospectiva
ingesta de vitamina D
metanálisis
revisión sistemática
cáncer colonrectal
incidencia
control de caso
prospectiva
Vitamin D Intake and the Risk of Colorectal Cancer: An Updated Meta-Analysis and Systematic Review of Case-Control and Prospective Cohort Studies
info:eu-repo/semantics/article
URL
https://openaccess.uoc.edu/bitstreams/62f2e771-97f3-461c-99a4-8d26a60343e6/download
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ef19f36dd741793cde673eb850ff40a4
4419489
application/pdf
Vitamin_D_Intake_and_the_Risk_of_Colorectal_Cancer_An_Updated_Meta_Analysis_and_Systematic_Review_of_Case_Control_and_Prospective_Cohort_Studies.pdf