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Title: Visualización mediante shiny de la calidad de los datos de RNA-Seq relacionados con el sistema inmune y el cáncer
Author: Ferrer Torres, Adrián
Director: Ventura Royo, Carles  
Morán Moreno, José Antonio
Tutor: Gonzalo Sanz, Ricardo
Others: Universitat Oberta de Catalunya
Keywords: Shiny
RNAseq
gene expression
quality control
Issue Date: Feb-2018
Publisher: Universitat Oberta de Catalunya
Abstract: Due to the increasing incidence of cancer in the population, it has become the second cause of death worldwide. Due to this, the study of the relation of the immune system with cancer disease is critical to research in what fails and how the expression on lymphocytic cells is modified. Therefore information about immune evasion would be reached leading to possible checkpoints or pharmacological target in which we could treat with different types of drugs, immunotherapy, or other therapies as personalized therapy. In order to conduct a study of genetic expression it is a must to first pre-filter, control and normalize the results obtained samples obtained from a RNA-Seq experiment. This is what is intended in this study, showing also the different stages of results obtained with graphics and tables in an application made with the shiny package. The samples were obtained from the gene expression omnibus webpage. The edgeR and DT packages were used for the application construction. It is as well included in the memory a report of the budget for a small lab and research center that sequences the client¿s genomes as well as other omic studies from other centers as hospitals, institutes and research centers.
Language: Spanish
URI: http://hdl.handle.net/10609/74347
Appears in Collections:Bachelor thesis, research projects, etc.

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