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http://hdl.handle.net/10609/126970
Title: | Coronavirus in children, bio-markers, infection severity and hospitalization |
Author: | Argüello González, Guillermo |
Tutor: | Burgos-Artizzu, Xavier Paolo Bonet-Carne, Elisenda |
Others: | Prados Carrasco, Ferran |
Abstract: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is typically very mild and often asymptomatic in children. Also, children and adolescents are less susceptible to the infection. Anyway, some children require hospitalization and rarely develop a severe multisystem inflammatory syndrome. Risk factors are widely studied in adults but there are not studies with large databases in children. Regarding IFN signature there is also little knowledge in its behaviour in children. Our goal is to bring new results in these two lines. Using generalized additive models we have found that risk factors in children are different than in adults. Risk factors in adults are comorbid conditions often considered acquired or probably related with unhealthy lifestyle but in children are congenital conditions. There are no significant gender differences in children. SOCS1 (suppressor of cytokine signaling 1) and CIITA (major histocompatibility complex class II transactivator) gene have an inverse relationship between them. We can use SOCS1 y CIITA levels, using a decision tree, to classify cases between mild and severe: low levels of CIITA and high of SOCS1 are related with severe cases. Finally, we observed that CIITA levels are higher in children than in adults. This could provide children protection against the infection and could open a new research line for treatments. |
Keywords: | children COVID-19 risk factors interferon cytokines |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | 25-Jan-2020 |
Publication license: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Appears in Collections: | Trabajos finales de carrera, trabajos de investigación, etc. |
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garguelloTFM0121memory.pdf | TFM memory | 1,32 MB | Adobe PDF | View/Open |
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