Please use this identifier to cite or link to this item: http://hdl.handle.net/10609/127086
|Interacción de síntomas neuropsiquiátricos, Poligenic risk scores y APOE en la conversión del deterioro cognitivo leve a demencia
|Alarcón Martín, Emilio
|New findings of genetic biomarkers as PRS would represent a new approachment to Alzheimer's disease risk evaluation. Data used in this study has been collected from GR@CE Project. 755 patients with low cognitive imparment are shown, in which conversion to demention is evaluted by GWAS data in PRS form (Alzheimer's disease as well as major depression), including demographic variables and neuropsychiatric symptoms. Using a Cox model to assess survival time, an HR was obtained both PRSAD and PRSMDD; 1.3 and 1.2 repectively when neuropsychiatric symptoms are key at the baseline visit. Age (HR= 1.05) and apathy (HR = 1.6) are used as key variables in conversion as well. Regarding the prediction of the depressive neuropsychiatric symptom, through a logistic regression model, we detected that sex is closely related (OR = 2.9), together with the other symptoms analyzed (Apathy OR = 3.4 // Anxiety OR = 6, 5). Certain trend has been found regarding to PRS, but the cohort does not have enough statistical power to discriminate the effect of those variables compared to the Discovery of genetic biomarkers in PRS form that would represent and advance in the Alzheimer's disease risk evaluation.
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|Memoria del TFM