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Title: Progresión radiográfica en pacientes con Espondiloartritis Axial en tratamiento con anti-TNF
Author: Llop Vilaltella, Maria
Director: Maceira, Marc  
Tutor: Fernández Martínez, Daniel  
Abstract: Background: Clinical efficacy of TNF inhibitors (TNFi) in axial spondyloarthritis (axSpA) has been widely probed in randomized control trials. In clinical practice, some studies suggested that long-term treatment with TNFi (more than 4 years) could slow down radiographic progression in axSpA. Furthermore, it is thought that the effect of TNFi on radiographic progression may be mediated by reducing disease activity. Objetive: To evaluate the relationship between disease activity and radiographic progression in axSpA patients treated with TNFi Methods: 101 patients with axSpA, from the Spanish Register of Biological Therapy in Spondyloarthritides (REGISPONSERBIO) were included in the analysis. To evaluate the relationship between disease activity (measured by ASDAS) with radiographic progression we have performed a multiple linear regression. The independent variable of radiographic progression used was the difference between the follow-up mSASSS with the initial one. The model predictors are adjusted according to the AIC method. Results: The multiple lineal regression model can explain the 61.8% of the observed variability in radiographic progression (R2: 0.6891, R2-Adjusted: 0.6182). The F test shows that it is significant (p value of 3.046e-10). The beta of the ASDAS difference variable is 0.893 (p= 0.011) with a 95% CI of 0.225-1.561. Conclusions: For each point of difference in ASDAS, the radiographic progression can be expected to increase by an average of 0.89. Meaning that the lower the clinical activity measured by ASDAS, the lower the radiographic progression measured by the mSASSS.
Keywords: EspAx
progresión radiográfica
Document type: info:eu-repo/semantics/masterThesis
Issue Date: May-2020
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