Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSanches, Clara-
dc.contributor.authorStengel, Chloé-
dc.contributor.authorGodard, Juliette-
dc.contributor.authorMertz, Justine-
dc.contributor.authorTeichmann, Marc-
dc.contributor.authorMigliaccio, Raffaella-
dc.contributor.authorValero Cabré, Antoni-
dc.contributor.otherUniversitat Oberta de Catalunya (UOC)-
dc.contributor.otherSorbonne Université-
dc.contributor.otherNational Reference Center for Rare or Early Onset Dementias-
dc.contributor.otherBoston University School of Medicine-
dc.identifier.citationSanches, C. [Clara], Stengel, C. [Chloé], Godard, J. [Juliette], Mertz, J. [Justine], Teichmann, M. [Marc], Migliaccio, R. [Raffaella] and Valero-Cabré, A. [Antoni] (2021). Past, Present, and Future of Non-invasive Brain Stimulation Approaches to Treat Cognitive Impairment in Neurodegenerative Diseases: Time for a Comprehensive Critical Review. Frontiers in Aging Neuroscience, 12, 1-41. doi: 10.3389/fnagi.2020.578339-
dc.description.abstractLow birth rates and increasing life expectancy experienced by developed societies have placed an unprecedented pressure on governments and the health system to deal effectively with the human, social and financial burden associated to aging-related diseases. At present, '24 million people worldwide suffer from cognitive neurodegenerative diseases, a prevalence that doubles every five years. Pharmacological therapies and cognitive training/rehabilitation have generated temporary hope and, occasionally, proof of mild relief. Nonetheless, these approaches are yet to demonstrate a meaningful therapeutic impact and changes in prognosis. We here review evidence gathered for nearly a decade on non-invasive brain stimulation (NIBS), a less known therapeutic strategy aiming to limit cognitive decline associated with neurodegenerative conditions. Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation, two of the most popular NIBS technologies, use electrical fields generated non-invasively in the brain to long-lastingly enhance the excitability/activity of key brain regions contributing to relevant cognitive processes. The current comprehensive critical review presents proof-of-concept evidence and meaningful cognitive outcomes of NIBS in eight of the most prevalent neurodegenerative pathologies affecting cognition: Alzheimer's Disease, Parkinson's Disease, Dementia with Lewy Bodies, Primary Progressive Aphasias (PPA), behavioral variant of Frontotemporal Dementia, Corticobasal Syndrome, Progressive Supranuclear Palsy, and Posterior Cortical Atrophy. We analyzed a total of 70 internationally published studies: 33 focusing on Alzheimer's disease, 19 on PPA and 18 on the remaining neurodegenerative pathologies. The therapeutic benefit and clinical significance of NIBS remains inconclusive, in particular given the lack of a sufficient number of double-blind placebo-controlled randomized clinical trials using multiday stimulation regimes, the heterogeneity of the protocols, and adequate behavioral and neuroimaging response biomarkers, able to show lasting effects and an impact on prognosis. The field remains promising but, to make further progress, research efforts need to take in account the latest evidence of the anatomical and neurophysiological features underlying cognitive deficits in these patient populations. Moreover, as the development of in vivo biomarkers are ongoing, allowing for an early diagnosis of these neuro-cognitive conditions, one could consider a scenario in which NIBS treatment will be personalized and made part of a cognitive rehabilitation program, or useful as a potential adjunct to drug therapies since the earliest stages of suh diseases. Research should also integrate novel knowledge on the mechanisms and constraints guiding the impact of electrical and magnetic fields on cerebral tissues and brain activity, and incorporate the principles of information-based neurostimulation.en
dc.publisherFrontiers in Aging Neuroscience-
dc.relation.ispartofFrontiers in Aging Neuroscience, 2021, 12-
dc.rightsCC BY-
dc.subjectneurodegenerative diseasesen
dc.subjectcognitive declineen
dc.subjectnon-invasive brain stimulation (nibs)en
dc.subjecttranscranial direct current stimulation (tdcs)en
dc.subjectbrain networksen
dc.subjectcognitive trainingen
dc.subjectmalalties neurodegenerativesca
dc.subjectdeteriorament cognitiuca
dc.subjectestimulació cerebral no invasiva (plomes)ca
dc.subjectestimulació transcranial de corrent continu (tdcs)ca
dc.subjectxarxes cerebralsca
dc.subjectentrenament cognitiuca
dc.subjectenfermedades neurodegenerativases
dc.subjectdeterioro cognitivoes
dc.subjectestimulación cerebral no invasiva (puntas)es
dc.subjectestimulación transcraneal de corriente directa (tdcs)es
dc.subjectredes cerebraleses
dc.subjectentrenamiento cognitivoes
dc.titlePast, present, and future of non-invasive brain stimulation approaches to treat cognitive impairment in neurodegenerative diseases: time for a comprehensive critical review-
Appears in Collections:Articles cientÍfics

Files in This Item:
File Description SizeFormat 
0000008579.pdf8,46 MBAdobe PDFThumbnail