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http://hdl.handle.net/10609/147529
Title: | Impacto de la dieta en el microbioma, su relación con el cáncer gastrointestinal y papel de los probióticos en su tratamiento |
Author: | Castiñeira Busto, María |
Tutor: | Ventura Wichner, Paula Sol |
Abstract: | Background. Gastrointestinal cancer is one of the most prevalent neoplasms globally and its incidence is expected to increase exponentially in the coming decades. The intestinal microbiota is a set of living microorganisms whose composition is influenced by exogenous factors, including diet. These microorganisms maintain the stability of the intestinal environment, with their alteration having been related to various gastrointestinal diseases, including cancer. Aims. To analyse the available evidence about the impact of different types of diet, as well as the use of probiotics, on the composition of the intestinal microbiota and its relationship with the development, prevention, and treatment of cancer. Materials and methods. Systematic review based on the PRISMA guideline of scientific papers about the influence of diets on the composition of the intestinal microbiota and the role of probiotic supplementation during the treatment of gastrointestinal cancer. Results. A total of 12 studies were included. The results indicate that Western-style diets promote a state of dysbiosis at the intestinal microbiota, increasing the bacterial species associated with a greater risk of development of gastrointestinal neoplasms, and that probiotic supplementation during chemotherapy and/or surgical treatment of gastrointestinal cancer provides benefits in terms of tolerance to therapies and in shortterm morbidity and mortality results. Conclusion: The modulation of changes in the intestinal microbiota through nutritional education to the population or the use of probiotics is postulated as a new strategy for the prevention, diagnosis and treatment of gastrointestinal cancer. |
Keywords: | gastrointestinal cancer Mediterranean diet probiotics chemotherapy synbiotics |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | Jan-2023 |
Publication license: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Appears in Collections: | Treballs finals de carrera, treballs de recerca, etc. |
Files in This Item:
File | Description | Size | Format | |
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mcastineirabTFM0123memoria.pdf | Memoria del TFM | 2,08 MB | Adobe PDF | View/Open |
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