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Title: | Análisis del contenido génico de dos inversiones polimórficas del cromosoma U en Drosophila subobscura |
Author: | Martínez Jordán, Jorge |
Tutor: | Orengo, Dorcas |
Others: | Merino, David |
Abstract: | The species Drosophila subobscura exhibits a rich inversion polymorphism, the frequency of which has been related to environmental conditions. This fact suggests that this type of polymorphisms constitute a genetic mechanism of adaptation to different climatic conditions. Thus, for the U chromosome, a higher frequency of the UST arrangement has been observed in cold climates whereas a higher frequency of the U1+2 arrangement has been observed in warm climates. It is hypothesized that these inversions have fixed sets of genes containing alleles coadapted to climatic conditions. However, the genetic content of these inversions has not been studied. In this context, this work was carried out with the aim of locating and characterizing inversion breakpoints for U1 and U2 in D. subobscura and examining the gene content of these inversions performing a gene ontology (GO) enrichment analysis The results have allowed us to determine that U2 was originated through nonhomologous end joining. Nevertheless, the results did not allow the establishment of the mechanism that originated the U1 inversion. Analysis of the genetic content of the inversions shows an enrichment of genes related to lipid metabolism and nephron morphosynthesis in U1, and genes related to nucleic acids metabolism in U2. Additionally, comparison of the genome of D. subobscura with the closely related species D. guanche has revealed a series of microinversions, probably caused by artifacts in the assembly of the latter. |
Keywords: | Drosophila subobscura chromosomal inversion gene ontology |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | Jan-2023 |
Publication license: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Appears in Collections: | Trabajos finales de carrera, trabajos de investigación, etc. |
Files in This Item:
File | Description | Size | Format | |
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jmartinezjordanTFM0123memoria.pdf | Memoria del TFM | 1,77 MB | Adobe PDF | View/Open |
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