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Title: | The complex relationship between infections and the development of autoimmune diseases |
Author: | Bayo Martin, Arturo |
Tutor: | Franco Serrano, Luis |
Others: | Perez-Alvarez, Nuria |
Abstract: | Autoimmune diseases (ADs) occur when the immune system attacks the body’s own healthy cells. Some of the most common ADs are: rheumatoid arthritis, lupus, celiac disease, multiple sclerosis, type 1 diabetes, and psoriasis. These diseases are indeed more common than most people realize, with estimates indicating that around 7.5% of the population in the United States and 4% of the global population suffer from at least one autoimmune disease. The prevalence of ADs appears to be increasing too, with yearly increases in the overall worldwide incidence and prevalence of autoimmune diseases of up to 19.1%, being more common in women than men (2-3 times higher propensity in women). The exact cause of ADs is not fully understood, but it is thought that a combination of genetic, environmental, and immune system factors may contribute to their development. Current treatments for ADs often involve medications that suppress the immune system, but since these can have significant side effects, researchers are working to develop more targeted and effective treatments that can specifically target the cells or pathways involved in ADs without suppressing the immune system as a whole. Some studies suggest that infections with certain types of bacteria or viruses may be associated with an increased risk of developing ADs. Confirming that relationship may lead to the development of more advanced, targeted treatments for certain ADs. This work explores that relationship for the most common ADs by analyzing their known epitopes against the complete proteome of all prokaryotic organisms. |
Keywords: | autoimmune diseases development autoantigens epitopes homology infections related with autoimmune diseases |
Document type: | info:eu-repo/semantics/masterThesis |
Issue Date: | 15-Jan-2023 |
Publication license: | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Appears in Collections: | Trabajos finales de carrera, trabajos de investigación, etc. |
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File | Description | Size | Format | |
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arturobayoTFM0623memoria.pdf | TFM report | 3,16 MB | Adobe PDF | View/Open |
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