Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10609/150210
Título : | Whole-brain diffusion tensor imaging predicts 6-month functional outcome in acute intracerebral haemorrhage |
Autoría: | Schwarz, G. Kanber, B. Prados, F. Browning, S. Simister, R. Jäger, H.R. Ambler, G. Gandini Wheeler-Kingshott, Claudia A.M. Werring, David |
Citación : | Schwarz, G. Kanber, B. Prados, F. Browning, S. Simister, R. · Jäger, H. R. Ambler, G. Gandini Wheeler‐Kingshott, C. A. M. Werring, D. Whole-brain diffusion tensor imaging predicts 6-month functional outcome in acute intracerebral haemorrhage. Journal of Neurology 270, 2640–2648 https://doi.org/10.1007/s00415-023-11592-7 |
Resumen : | Introduction Small vessel disease (SVD) causes most spontaneous intracerebral haemorrhage (ICH) and is associated with widespread microstructural brain tissue disruption, which can be quantified via diffusion tensor imaging (DTI) metrics: mean diffusivity (MD) and fractional anisotropy (FA). Little is known about the impact of whole-brain microstructural alterations after SVD-related ICH. We aimed to investigate: (1) association between whole-brain DTI metrics and functional outcome after ICH; and (2) predictive ability of these metrics compared to the pre-existing ICH score. Methods Sixty-eight patients (38.2% lobar) were retrospectively included. We assessed whole-brain DTI metrics (obtained within 5 days after ICH) in cortical and deep grey matter and white matter. We used univariable logistic regression to assess the associations between DTI and clinical-radiological variables and poor outcome (modified Rankin Scale > 2). We deter- mined the optimal predictive variables (via LASSO estimation) in: model 1 (DTI variables only), model 2 (DTI plus non-DTI variables), model 3 (DTI plus ICH score). Optimism-adjusted C-statistics were calculated for each model and compared (likelihood ratio test) against the ICH score. Results DeepgreymatterMD(OR1.04[95%CI1.01–1.07],p=0.010)andwhitematterMD(OR1.11[95%CI1.01–1.23], p = 0.044) were associated (univariate analysis) with poor outcome. Discrimination values for model 1 (0.67 [95% CI 0.52–0.83]), model 2 (0.71 [95% CI 0.57–0.85) and model 3 (0.66 [95% CI 0.52–0.82]) were all significantly higher than the ICH score (0.62 [95% CI 0.49–0.75]). Conclusion Our exploratory study suggests that whole-brain microstructural disruption measured by DTI is associated with poor 6-month functional outcome after SVD-related ICH. Whole-brain DTI metrics performed better at predicting recovery than the existing ICH score. |
Palabras clave : | intracerebral haemorrhage outcome prediction fractional anisotropy mean diffusivity ICH score whole- brain approach |
DOI: | https://doi.org/10.1007/s00415-023-11592-7 |
Tipo de documento: | info:eu-repo/semantics/article |
Versión del documento: | info:eu-repo/semantics/acceptedVersion |
Fecha de publicación : | 2-may-2023 |
Aparece en las colecciones: | Articles |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Scwarz_Whole_JoN.pdf | 821,96 kB | Adobe PDF | Visualizar/Abrir | |
Scwarz_Whole_JoN_.pdf | 876,77 kB | Adobe PDF | Visualizar/Abrir |
Comparte:
Los ítems del Repositorio están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.