Por favor, use este identificador para citar o enlazar este ítem:
http://hdl.handle.net/10609/150399
Título : | Effects of walnut consumption for 2 years on older adults' bone health in the Walnuts and Healthy Aging (WAHA) trial |
Autoría: | Oliver Pons, Carla Sala-Vila, Aleix Cofan, Montserrat Serra-Mir, Mercè Roth, Irene Valls-Pedret, Cinta Domenech, Monica Ortega Martinez de Victoria, Emilio Rajaram, Sujatha Sabate, Joan Ros, Emilio Chiva-Blanch, Gemma |
Citación : | Oliver‐Pons, C. [Carla], Sala‐Vila, A. [Aleix], Cofán, M. [Montserrat], Serra‐Mir, M. [Mercè], Roth, I. [Irene], Valls‐Pedret, C. [Cinta], ... & Chiva‐Blanch, G. [Gemma].(2024). Effects of walnut consumption for 2 years on older adults' bone health in the Walnuts and Healthy Aging (WAHA) trial. Journal of the American Geriatrics Society, 0(0), 1-12. doi: 10.1111/jgs.19007 |
Resumen : | Background. Nutritional strategies to maintain bone health in aging individuals are of great interest. Given the beneficial nutrient composition of walnuts, rich in alpha-linolenic (the vegetable n-3 fatty acid) and polyphenols, their regular consumption might be a dietary option to reduce age-related bone loss. We determined whether daily walnut consumption improves bone mineral density (BMD) and circulating biomarkers of bone turnover. Methods. The Walnuts and Healthy Aging study (WAHA) is a two-center, parallel, randomized controlled trial evaluating the effect of a diet enriched with walnuts at ≈15% energy compared with a control diet for 2 years on agerelated health outcomes in healthy men and women aged 63–79 years. Changes in BMD were a prespecified secondary outcome only at the Barcelona node of the trial, where 352 participants were randomized. Retention rate was 92.6%. Primary endpoints were 2-year changes in BMD at the spine and the nondominant femoral neck, determined by dual-energy X-ray absorptiometry (DXA). Secondary endpoints were 2-year changes in bone turnover biomarkers (adrenocorticotropic hormone, Dickkopf WNT signaling pathway inhibitor-1, osteoprotegerin, osteocalcin, osteopontin, sclerostin, parathyroid hormone, and fibroblast growth factor-23), which were quantified in 211 randomly selected participants. Results. The walnut diet versus the control diet had no effect on 2-year changes in BMD at the spine (0.15% vs. 0.35%, p = 0.632) and femoral neck ( 0.90% vs. 0.70%, p = 0.653), or on bone turnover biomarkers. Results were similar in participants treated or not with bone resorption inhibitors or those with or without osteoporosis/osteopenia at inclusion. Conclusions. Compared with the usual diet, a diet enriched with walnuts at 15% of energy for 2 years failed to improve BMD or circulating markers of bone metabolism in healthy older people. |
Palabras clave : | bone mineral density and turnover biomarkers walnuts randomized controlled trial nutrition |
DOI: | https://doi.org/10.1111/jgs.19007 |
Tipo de documento: | info:eu-repo/semantics/article |
Versión del documento: | info:eu-repo/semantics/publishedVersion |
Fecha de publicación : | 31-may-2024 |
Licencia de publicación: | http://creativecommons.org/licenses/by-nc-nd/4.0/es/ |
Aparece en las colecciones: | Articles |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Oliver_JAGS_Effects.pdf | 983,86 kB | Adobe PDF | Visualizar/Abrir |
Comparte:
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons