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DC Field | Value | Language |
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dc.contributor.author | Oliver Pons, Carla | - |
dc.contributor.author | Sala-Vila, Aleix | - |
dc.contributor.author | Cofan, Montserrat | - |
dc.contributor.author | Serra-Mir, Mercè | - |
dc.contributor.author | Roth, Irene | - |
dc.contributor.author | Valls-Pedret, Cinta | - |
dc.contributor.author | Domenech, Monica | - |
dc.contributor.author | Ortega Martinez de Victoria, Emilio | - |
dc.contributor.author | Rajaram, Sujatha | - |
dc.contributor.author | Sabate, Joan | - |
dc.contributor.author | Ros, Emilio | - |
dc.contributor.author | Chiva-Blanch, Gemma | - |
dc.date.accessioned | 2024-06-03T13:34:35Z | - |
dc.date.available | 2024-06-03T13:34:35Z | - |
dc.date.issued | 2024-05-31 | - |
dc.identifier.citation | Oliver‐Pons, C. [Carla], Sala‐Vila, A. [Aleix], Cofán, M. [Montserrat], Serra‐Mir, M. [Mercè], Roth, I. [Irene], Valls‐Pedret, C. [Cinta], ... & Chiva‐Blanch, G. [Gemma].(2024). Effects of walnut consumption for 2 years on older adults' bone health in the Walnuts and Healthy Aging (WAHA) trial. Journal of the American Geriatrics Society, 0(0), 1-12. doi: 10.1111/jgs.19007 | - |
dc.identifier.issn | 0002-8614MIAR | - |
dc.identifier.uri | http://hdl.handle.net/10609/150399 | - |
dc.description.abstract | Background. Nutritional strategies to maintain bone health in aging individuals are of great interest. Given the beneficial nutrient composition of walnuts, rich in alpha-linolenic (the vegetable n-3 fatty acid) and polyphenols, their regular consumption might be a dietary option to reduce age-related bone loss. We determined whether daily walnut consumption improves bone mineral density (BMD) and circulating biomarkers of bone turnover. Methods. The Walnuts and Healthy Aging study (WAHA) is a two-center, parallel, randomized controlled trial evaluating the effect of a diet enriched with walnuts at ≈15% energy compared with a control diet for 2 years on agerelated health outcomes in healthy men and women aged 63–79 years. Changes in BMD were a prespecified secondary outcome only at the Barcelona node of the trial, where 352 participants were randomized. Retention rate was 92.6%. Primary endpoints were 2-year changes in BMD at the spine and the nondominant femoral neck, determined by dual-energy X-ray absorptiometry (DXA). Secondary endpoints were 2-year changes in bone turnover biomarkers (adrenocorticotropic hormone, Dickkopf WNT signaling pathway inhibitor-1, osteoprotegerin, osteocalcin, osteopontin, sclerostin, parathyroid hormone, and fibroblast growth factor-23), which were quantified in 211 randomly selected participants. Results. The walnut diet versus the control diet had no effect on 2-year changes in BMD at the spine (0.15% vs. 0.35%, p = 0.632) and femoral neck ( 0.90% vs. 0.70%, p = 0.653), or on bone turnover biomarkers. Results were similar in participants treated or not with bone resorption inhibitors or those with or without osteoporosis/osteopenia at inclusion. Conclusions. Compared with the usual diet, a diet enriched with walnuts at 15% of energy for 2 years failed to improve BMD or circulating markers of bone metabolism in healthy older people. | en |
dc.format.mimetype | application/pdf | ca |
dc.language.iso | eng | en |
dc.publisher | Wiley | ca |
dc.relation.ispartof | Journal of the American Geriatrics Society, 2024 | - |
dc.relation.uri | https://doi.org/10.1111/jgs.19007 | - |
dc.rights | CC BY-NC-ND | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/es/ | - |
dc.subject | bone mineral density and turnover biomarkers | en |
dc.subject | walnuts | en |
dc.subject | randomized controlled trial | en |
dc.subject | nutrition | en |
dc.title | Effects of walnut consumption for 2 years on older adults' bone health in the Walnuts and Healthy Aging (WAHA) trial | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.doi | https://doi.org/10.1111/jgs.19007 | - |
dc.gir.id | AR-0000011629 | - |
dc.type.version | info:eu-repo/semantics/publishedVersion | - |
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