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Title: Caracterización transcriptómica del cáncer de endometrio y su importancia en el diseño de nuevas estrategias terapéuticas
Author: Parra Grande, Mónica
Tutor: Luna Cornadó, Jeroni
Others: Merino, David  
Keywords: RNA-seq
endometrial cancer
targeted therapy
Issue Date: 5-Jun-2018
Publisher: Universitat Oberta de Catalunya (UOC)
Abstract: Endometrial cancer is the most frequent gynecological tumor in development countries. Currently there is a lack of therapeutic options in this type of tumors, which gives rise to a great interest in the search for therapeutic targets that allows the treatment to be customized for the benefit of the patient. The objective of the project was to find out significant differences in the expression of the genes in patients with MSI-H endometrial cancer against MSI-L and MSS, with the objective of finding possible therapeutics options. Methods: To carry out the study, data were obtained from the RNA-seq analysis of samples from patients with TCGA endometrial cancer. The differential expression analysis was carried out using the limma package. Subsequently an analysis of pathway enrichment and gene co-expression was carried out using the ReactomeFIPlugin application through cytoscape version 3.6.1. Finally, the study was completed with a survival analysis of both groups.
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